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Immunomodulatory Agents in Bacterial Infectious Diseases: A Therapeutic Perspective

Call for Papers

Infectious diseases are caused by pathogens such as bacteria, virus, fungi, or parasites. According to WHO, these diseases have been one leading cause of human morbidity and mortality worldwide. Interest has focused on the increasing incidence of antimicrobial-resistant infectious diseases that limit the success of the current available antimicrobial treatments and on the development of a wide range of strategies, by the pathogens, to evade the host immune system, which also impact on the resolution of infections. For these reasons, new nonconventional approaches to improve treatment outcomes have drawn attention to finding effective therapies. An attractive alternative is to apply immunomodulatory agents that regulate the host immune response, avoiding the establishment of infections or achieving their resolution. Indeed, the continuous discovery of immunomodulatory agents has increased their potential as new nonconventional treatments against bacterial human or animal infectious diseases, as well as inflammatory diseases. These possibilities strengthen the usefulness of studying the biological properties and applied properties of immunomodulatory agents.

This special issue focuses mainly on high-quality original research as well as review articles that highlight the contribution of immunomodulatory agents, such as regulators of innate and adaptive immunity, to the development of new therapies for the control of bacterial infectious diseases that impact on human and animal health.

Potential topics include but are not limited to the following:

  • Natural or synthetic immunomodulatory agents that improve host defense mechanism, leading to increasing therapeutic outcomes
  • Nonconventional anti-infective agents including host defense peptides
  • Agents for host-directed therapy which target host factor required by bacteria for replication or persistence such as micronutrients, recombinant proteins, synthetic nucleic acids, cellular therapy, and cytokines
  • Natural plant immunomodulatory compounds such as plant extracts or essential oils

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 4 May 2018
Publication DateSeptember 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

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