Journal of Immunology Research

Immune Interactions in Nanomaterial Pharmacodynamics


Publishing date
01 Dec 2021
Status
Closed
Submission deadline
23 Jul 2021

Lead Editor

1Technical University Gheorghe Asachi Iasi, Iasi, Romania

2Tyndall National Institute, Cork, Ireland

3Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

4Institute of Macromolecular Chemistry Petru Poni, Iasi, Romania

5National Institute for Laser, Plasma & Radiation Physics, Bucharest, Romania

This issue is now closed for submissions.

Immune Interactions in Nanomaterial Pharmacodynamics

This issue is now closed for submissions.

Description

By either design or repurposing, emerging nanomedicines evolve as important agents targeting biochemical gears as key nominal or herded interactors, often by synchronising/aligning their functions with the host biological timelines through some machine-like features (e.g., conditional release, discriminative localization, and activation). Since almost all in vivo molecular presence is monitored by various layers of immune defense, local or abscopal, broad reactive ripples induced by the immune system may tamper with pharmacodynamics. Moreover, they might affect the efficiency of these promising therapeutic agents. Formally, immunity can be described as a molecular system either hard wired (innate) or programmable (acquired immunity), which provides a spectrum of treatments focused on the recognition of molecular individualities (immune identities). Such immune identities, acting as immune stimuli or targets, might internally be perceived in various scenarios by complementary receptors as microbial-associated molecules, self catastrophic or homeostatic damage molecules, intercellular and intracellular control molecular operators, in innate immunity, or as antigens, in adaptive immunity.

There is great heterogeneity in both the spatial and temporal profiles of immune responses, resulting in a spectrum of contradictory biological outcomes that discriminate histological compartments; central nervous system or stem cell niches as immune sanctuaries, mucosal surfaces and connective tissue as operational theatre scene, and physiological processes (cellular turnover; metabolic control; pregnancy). Thus, given the ubiquity and vigilance of the defense mechanisms, immune components are intrinsically involved in many pharmacologic effects and outcomes. In some instances, they may even address the pharmacological agent or its derivatives, either as a target (i.e., allergen or inflammatory stimuli) or as a carrier for host-derived regulatory factors. The immune visibility of nanomedicines is yet to be understood and sieved for their practical exploits. Under these conditions, continued review of the immune impact of nanoformulations is both informative and inspiring for progress in the field. It is also helpful for defining opportunities besides empirically found constraints. Moreover, it enhances the rationale of pharmacological routine.

The aim of this Special Issue is to solicit original research articles highlighting recent findings in understanding how immune system components, and responses are involved in the pharmacodynamics of nanomedicine. Submissions focusing on formulating the rationale/principles for new, unconventional approaches in the design, and functionality of these new classes of drugs are also encouraged. Review articles discussing the state of the art are also welcome.

Potential topics include but are not limited to the following:

  • Bioinformatics, and modelling approaches in predicting the immune impact of nanoconjugates
  • Structural constraints in nanoconjugates allowing binding, and modulation of innate immune receptors
  • Structural features of nanomedicine enabling the harness of tolerogenic versus destructive specific, polarised immune responses
  • Inflammatory potential and mechanisms of nanoformulations, and their derivatives
  • Structural designs relying on polarised immune responses in activating nanomedicines
  • Drug delivery systems, mechanisms, and modelling of drug release
  • Impact of new drug delivery systems on the immune system
  • Fractal dynamics interpretation of intercellular communication
  • Nonlinear theoretical models in drug delivery
Journal of Immunology Research
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Acceptance rate11%
Submission to final decision121 days
Acceptance to publication27 days
CiteScore6.000
Journal Citation Indicator0.560
Impact Factor4.1
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