Journal of Immunology Research

Neutrophils: Their Role in Innate and Adaptive Immunity 2017


Status
Published

Lead Editor

1Universidad Nacional Autónoma de México, Mexico City, Mexico

2CINVESTAV-IPN, Mexico City, Mexico

3University of California, San Francisco, USA


Neutrophils: Their Role in Innate and Adaptive Immunity 2017

Description

Neutrophils are the most abundant leukocytes in the blood and constitute the first line of host defense against numerous infectious pathogens, including bacteria, fungi, protozoa, and large parasites. Neutrophils migrate to sites of inflammation and infection where they recognize and phagocytose invading microorganisms in order to kill them via different cytotoxic mechanisms. These include the production of reactive oxygen species, microbicidal substances stored in granules, and the release of their nuclear material in the form of neutrophil extracellular traps.

In recent years, it has become evident that neutrophils not only have a fundamental role in the acute phase of inflammation when they actively eliminate pathogens, but also are capable of modifying the overall immune response. Neutrophils can do this by exchanging information with macrophages, dendritic cells, and other cells of the adaptive immune system through either soluble mediators or direct cell-cell contact. In addition, neutrophils are being recognized as important players in cancer and atherosclerosis, as these cells can infiltrate tumors and the atherosclerotic plaque. Thus, neutrophils can have an influence on tumor progression and inflammation leading to various stages of atherosclerosis. It is then important to understand the role of neutrophils in these disorders in order to be able to regulate their function to alleviate these health problems.

The purpose of this special issue is to publish high-quality original research papers as well as review articles addressing recent issues on the role of neutrophils in shaping the immune response and the consequences this may have on important health issues such as resolution of inflammation, autoimmunity, and cancer.

Potential topics include but are not limited to the following:

  • Phagocytosis
  • Neutrophil extracellular traps
  • Signal transduction pathways regulating neutrophil activation
  • Neutrophil homeostasis
  • Resolution of inflammation
  • Neutrophils in atherosclerosis
  • Neutrophils in cancer
  • Role of neutrophils against larger parasites such as Toxoplasma and Leishmania
  • Regulation of neutrophil function
  • Neutrophils as therapeutic targets

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 9748345
  • - Editorial

Neutrophils: Their Role in Innate and Adaptive Immunity 2017

Carlos Rosales | Clifford A. Lowell | ... | Eileen Uribe-Querol
  • Special Issue
  • - Volume 2017
  • - Article ID 6530531
  • - Research Article

Cxcl8b and Cxcr2 Regulate Neutrophil Migration through Bloodstream in Zebrafish

Constanza Zuñiga-Traslaviña | Karina Bravo | ... | Carmen G. Feijóo
  • Special Issue
  • - Volume 2017
  • - Article ID 5273201
  • - Review Article

Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease

Carina Kärrman Mårdh | James Root | ... | Matthew Thomas
  • Special Issue
  • - Volume 2017
  • - Article ID 6710278
  • - Review Article

Advanced Role of Neutrophils in Common Respiratory Diseases

Jinping Liu | Zhiqiang Pang | ... | Fang Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 7915975
  • - Review Article

Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models

Gang Huang | Xu-Chen Xu | ... | Zhi-Hua Chen
  • Special Issue
  • - Volume 2017
  • - Article ID 4347121
  • - Research Article

Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils

Thornin Ear | Olga Tatsiy | ... | Patrick P. McDonald
  • Special Issue
  • - Volume 2017
  • - Article ID 2896380
  • - Review Article

Neutrophil Extracellular Traps and Microcrystals

Balázs Rada
  • Special Issue
  • - Volume 2017
  • - Article ID 5140679
  • - Review Article

Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke

Johanna Ruhnau | Juliane Schulze | ... | Antje Vogelgesang
  • Special Issue
  • - Volume 2017
  • - Article ID 9671604
  • - Review Article

Neutrophils and Immunity: From Bactericidal Action to Being Conquered

Tie-Shan Teng | Ai-ling Ji | ... | Yan-Zhang Li
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision60 days
Acceptance to publication33 days
CiteScore5.100
Impact Factor3.327
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