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Immune Response in the Liver under Conditions of Infection, Malignancy, and Transplantation

Call for Papers

The liver is the largest solid organ in the body and commands a large blood supply that is rich in bacterial products, environment toxins, and food antigens, which are repeatedly scanned by cells within the liver. In addition, the regenerative capability of liver tissue makes it unique in comparison to other internal organs. In contrast to these beneficial properties, the liver is one of the most common sites for metastatic diseases; it supports chronic viral infections caused by hepatitis B and C and can also promote tolerance against external antigens in animal models. Furthermore, interestingly, liver transplantation often requires less immunosuppression compared to kidney and other solid organ transplantations. Despite these properties, the study of liver immunology remains in its infancy, and many questions remain unanswered. Can we accept the liver as a peripheral organ of the immune system? In which cases and by what mechanism does the liver alter tolerance and immunity? What are the risks and outcomes of infections after liver transplantation? Finally, what is the role of the liver during the immunization process?

We invite authors to submit original clinical or experimental research and review articles that seek to define the relationship between the liver and the immune system during infection, malignancy, and transplantation. We are particularly interested in articles describing the role of the immune system in the liver at the molecular and cellular levels. Potential topics include, but are not limited to:

  • The liver and its role in the immune system
  • Immunopathogenesis of liver diseases
  • Viral infections and immunity in the liver
  • Hepatocellular carcinoma and the immune response
  • Metastatic liver cancer and the immune response
  • Immunotherapeutic approaches to liver diseases
  • Infection and immune suppression after liver transplantation
  • Vaccination and preventable infections in liver transplant recipients and patients with chronic hepatitis

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

Manuscript DueFriday, 2 August 2013
First Round of ReviewsFriday, 25 October 2013
Publication DateFriday, 20 December 2013

Lead Guest Editor

  • Basak Kayhan, Department of Immunology, Faculty of Medicine, Liver Transplantation Institute, İnönü University, Malatya, Turkey

Guest Editors

  • Sukru Oguz Ozdamar, Department of Pathology, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey
  • Winfried Padberg, Department of Surgery, Giessen University, Giessen, Germany
  • Uner Kayabas, Department of Infectious Diseases and Clinical Microbiology, İnönü University Faculty of Medicine, Malatya, Turkey
  • Rina Aharoni, Weizmann Institute of Science, Rehovot, Israel
  • Saied Mirshahidi, Department of of Medicine, Basic Science & Biospecimen Laboratory, Loma Linda University Cancer Center, USA