Prevalence of Coronary Endothelial and Microvascular Dysfunction in Women with Symptoms of Ischemia and No Obstructive Coronary Artery Disease Is Confirmed by a New Cohort: The NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation–Coronary Vascular Dysfunction (WISE-CVD)

Table 2

A comparison of coronary reactivity measures in the original and contemporary WISE cohorts.

	1997-2001	2009-2011	p
Endothelial-Independent Coronary Reactivity (CFR-Ado)	n=162	n=222
Mean CFR-Ado	2.6 ± 0.8	2.7 ± 0.6	0.35
Median (IQR)	2.5 (2.1, 3.0)	2.6 (2.2, 2.9)	0.26
% with CFR < 2.5	48	40	0.12
% with CFR <2.32	36	31	0.27
Endothelial-Dependent Reactivity (Δ Diam to ACH)	n=107	n=162
Mean Δ Diam	1.6 ± 12.8	0.2 ± 10.0	0.34
Median (IQR)	2.6 (-6.4, +10.0)	-0.6 (-6.4, +6.5)	0.14
% with Δ Diam ≤ 0% (abnormal)	44	54	0.10
Endothelial-Independent Reactivity (Δ Diam to NTG)	n=113	n=170
Mean Δ Diam	9.8 ± 13.5	9.7 ± 13.0	0.94
Median (IQR)	8.3 (2.8, 17.1)	7.6 (1.3, 18.8)	0.87
% with Δ Diam ≤ 20% (abnormal)	83	78	0.28

p-values by t-test, Kruskal-Wallis test, and Chi Square, where appropriate.
CFR-Ado = coronary flow reserve in response to adenosine; IQR=inter-quartile range; ACH = acetylcholine; NTG = nitroglycerin.