Brain Natriuretic Peptide for Predicting Contrast-Induced Acute Kidney Injury in Patients with Acute Coronary Syndrome Undergoing Coronary Angiography: A Systematic Review and Meta-Analysis

Table 1

Characteristics of included studies.

Marker	Study	Study type	Definition of CI-AKI	Population	No. of patients	Male/female	Mean age
BNP	Akgul et al. 2013 [40]	Prospective	An absolute increase in SCr of ≥0.3 mg/dl or ≥50% from the baseline	STEMI patients undergoing PCI	424	340/84	55.3 ± 12.0
	Moltrasio et al. 2014 [39]	Prospective	An absolute increase in SCr of ≥0.3 mg/dl	ACS patients undergoing PCI	639	484/155	70.6 ± 12.5
	Tung et al. 2015 [38]	Prospective	An absolute increase in SCr of ≥0.3 mg/dl or ≥50% from the baseline	STEMI patients undergoing PCI	189	163/26	62.6 ± 13.9
	Parenica et al. 2020 [35]	Retrospective	An absolute increase in SCr of ≥0.3 mg/dl or ≥50% from the baseline	STEMI patients undergoing PCI	427	328/99	73 (45–83) 62 (45–78)
NT-proBNP	Kurtul et al. 2014 [25]	Prospective	An increase in SCr of ≥0.5 mg/dL or ≥25% above baseline within 72 hours after contrast administration	ACS patients undergoing PCI	436	280/156	62.27 ± 13.01
	Liu et al. 2016 [24]	Prospective	An increase in SCr of >0.5 mg/dL above baseline within 48 to 72 hours after contrast administration	STEMI patients undergoing PCI	283	NA	62.9 ± 12.3
	Agarwal et al. 2018 [23]	Prospective	An increase in SCr of ≥0.5 mg/dL or ≥25% above baseline within 48 hours after index angiography	ACS patients undergoing PCI	150	96/54	63.03 ± 9.07
	Kopytsya et al. 2018 [37]	Retrospective	An absolute increase in SCr of ≥0.3 mg/dl from the baseline within 48 hours	STEMI patients undergoing SCAG	68	NA	NA
	Alan et al. 2019 [36]	Prospective	An absolute increase in SCr of ≥0.3 mg/dl at 48 h of injection or >50% above baseline within 72 hours after contrast administration	ACS patients undergoing coronary angiography	216	170/46	63.9 ± 12.3

BNP, B-type natriuretic peptide; NT-proBNP, N-terminal pro-B-type natriuretic peptide; CI-AKI, contrast-induced acute kidney injury; SCr, serum creatinine; ACS, acute coronary syndrome; STEMI, ST-elevation myocardial infarction; PCI, percutaneous coronary intervention; SCAG, selective coronary angiography; NA, not available; median (5th–95th percentile ranges).