Percutaneous Coronary Intervention Complexity and Risk of Adverse Events in relation to High Bleeding Risk among Patients Receiving Drug-Eluting Stents: Insights from a Large Single-Center Cohort Study
Table 1
Baseline characteristics according to PCI complexity.
Complex PCI (n = 3651)
Noncomplex PCI (n = 6516)
value
Baseline characteristics
Age, years
58.62 ± 10.00
58.15 ± 10.39
0.026
Male
2897 (79.3)
4944 (75.9)
<0.001
Body mass index, kg/m2
26.05 ± 3.17
25.86 ± 3.19
0.003
Hypertension
2413 (66.1)
4128 (63.4)
0.006
Diabetes mellitus
1202 (32.9)
1840 (28.2)
<0.001
Dyslipidemia
2498 (68.4)
4339 (66.6)
0.059
Chronic kidney disease
158 (4.3)
246 (3.8)
0.171
Current smoker
2137 (58.5)
3677 (56.4)
0.040
Prior MI
825 (22.6)
1095 (16.8)
<0.001
Prior PCI
968 (26.5)
1453 (22.3)
<0.001
Prior CABG
182 (5.0)
221 (3.4)
<0.001
Prior cerebrovascular event
396 (10.8)
684 (10.5)
0.584
Prior PAD
108 (3.0)
159 (2.4)
0.117
LVEF, (%)
62.44 ± 7.40
63.07 ± 7.14
<0.001
ACS
2058 (56.4)
4036 (61.9)
<0.001
Hemoglobin, g/dL
14.29 ± 1.52
14.30 ± 1.54
0.878
Platelet count, 109/L
204.01 ± 52.84
206.63 ± 56.71
0.022
White blood cell count, 109/L
6.78 ± 1.64
6.72 ± 1.71
0.122
eGFR, ml/min/1.73 m2
94.68 ± 18.77
95.27 ± 18.35
0.125
PARIS thrombotic risk score
2.60 ± 1.73
2.46 ± 1.65
<0.001
PARIS bleeding risk score
3.72 ± 2.08
3.70 ± 2.08
0.600
Duration of DAPT, days
577.86 ± 209.19
563.29 ± 207.40
<0.001
Procedural characteristics
Target vessel location
Left main
268 (7.3)
0 (0.0)
<0.001
Left anterior descending artery
3036 (83.2)
6139 (94.2)
<0.001
Left circumflex artery
1283 (35.1)
525 (8.1)
<0.001
Right coronary artery
1402 (38.4)
473 (7.3)
<0.001
Bypass graft
10 (0.3)
7 (0.1)
0.049
In-stent restenosis target lesion
447 (12.2)
0 (0.0)
<0.001
Heavy calcified lesion (using rotablation)
52 (1.4)
0 (0.0)
<0.001
Thrombotic lesion
169 (4.6)
226 (3.5)
0.004
Type B2/C lesion
3335 (91.3)
4477 (68.7)
<0.001
SYNTAX score
15.0 (9.0–21.0)
8.0 (5.0–13.0)
<0.001
Total lesion length, mm
60.0 (42.0–76.0)
24.0 (16.0–35.0)
<0.001
Number of vessels treated
1
1798 (49.2)
5888 (90.4)
<0.001
2
1626 (44.5)
628 (9.6)
<0.001
3
227 (6.2)
0 (0.0)
<0.001
Number of lesions stented
1.88 ± 0.83
1.16 ± 0.37
<0.001
Number of stents implanted
2.86 ± 1.13
1.39 ± 0.49
<0.001
Bifurcation treated with 2 stents
428 (11.7)
0 (0.0)
<0.001
Chronic total occlusion treated
836 (22.9)
0 (0.0)
<0.001
Total stent length, mm
64.0 (45.0–81.0)
28.0 (18.0–38.0)
<0.001
Total stent length>60 mm
2052 (56.2)
0 (0.0)
<0.001
Mean stent diameter, mm
2.90 ± 0.53
3.08 ± 0.56
<0.001
Glycoprotein IIb/IIIa use
801 (21.9)
848 (13.0)
<0.001
Type of DES implanted
0.503
Early-generation DES
388 (10.6)
665 (10.2)
New-generation DES
3263 (89.4)
5851 (89.8)
Radial approach
3274 (89.7)
5997 (92.0)
<0.001
Use of intravascular ultrasound
338 (9.3)
212 (3.3)
<0.001
Values are mean ± SD or median (interquartile range) for continuous variables, and n (%) for categorical variables. ACS = acute coronary syndrome (s); CAD = coronary artery disease; CABG = coronary artery bypass grafting; DAPT = dual antiplatelet therapy; DES = drug-eluting stents; EF = ejection fraction; LVEF = left ventricular ejection fraction; MI = myocardial infarction; NSTEMI = non-ST-segment elevation myocardial infarction; PAD = peripheral artery disease; PCI = percutaneous coronary intervention; PARIS= Patterns of Nonadherence to Antiplatelet Regimen in Stented Patients; STEMI = ST-segment elevation myocardial infarction.
