Research Article
Usefulness of the Hybrid RFR-FFR Approach: Results of a Prospective and Multicenter Analysis of Diagnostic Agreement between RFR and FFR—The RECOPA (REsting Full-Cycle Ratio Comparation versus Fractional Flow Reserve (A Prospective Validation)) Study
Figure 4
Comparison of the hybrid RFR-FFR strategy versus the exclusive FFR strategy for an agreement of at least 95%. The hybrid RFR-FFR strategy only misclassified 18 lesions (7 false positives and 11 false negatives), diminishing the percentage of lesions requiring the administration of vasodilators to 42% (158 lesions from a total of 380 lesions) compared to the exclusive FFR strategy. Red dots represent the disagreement and black dots represent the agreement between the two strategies. Grey dots should be reclassified by administration of vasodilators and determination of FFR. Two adenosine-free zones (blue) were established (RFR < 0.86 and RFR < 0.92). The adenosine zone (grey) falls between the RFR values of 0.86 and 0.92, with both included.