COlchicine to Prevent PeriprocEdural Myocardial Injury in Percutaneous Coronary Intervention (COPE-PCI): Coronary Microvascular Physiology Pilot Substudy

Table 3

Combined pre-PCI, post-PCI, and change in invasive coronary physiological and laboratory measurements, by study drug randomization.

	Colchicine (n = 24)	Placebo (n = 26)	value
Invasive coronary physiological measurements
FFR
Pre-PCI	0.65 (0.47–0.79)	0.72 (0.52–0.80)	0.42^‡
Post-PCI	0.88 (0.83–0.93)	0.90 (0.81–0.93)	0.79^‡
Change	0.19 (0.09–0.38)	0.13 (0.07–0.33)	0.45^‡
Tmn rest
Pre-PCI	0.82 (0.57–1.55)	1.19 (0.54–1.59)	0.73^‡
Post-PCI	0.89 (0.52–1.44)	0.64 (0.39–1.09)	0.16^‡
Change	0.01 (−0.30–0.23)	−0.31 (−0.80–0.01)	0.03^‡
Tmn hyperaemia
Pre-PCI	0.38 (0.31–0.69)	0.45 (0.20–0.78)	0.87^‡
Post-PCI	0.26 (0.14–0.45)	0.26 (0.16–0.46)	0.57^‡
Change	−0.12 (−0.43–0.11)	−0.12 (−0.43–0.04)	0.84^‡
CFR
Pre-PCI	2.10 (1.40–2.70)	1.95 (1.38–3.30)	0.92‡
Post-PCI	3.25 (2.08–4.40)	2.00 (1.48–3.30)	0.03^‡
Change	1.20 (−0.30–2.10)	0.10 (−0.70–0.63)	0.03^‡
BRI
Pre-PCI	54.40 (21.83–96.63)	47.65 (26.63–106.00)	0.79^‡
Post-PCI	73.55 (44.05–122.67)	54.37 (30.73–95.52)	0.25^‡
Change	15.86 (−1.53–40.29)	−5.16 (−41.10–17.76)	0.052^‡
IMR
Pre-PCI	21.30 (11.50–26.80)	18.05 (9.95–32.28)	0.97^‡
Post-PCI	17.02 (10.40–31.43)	19.92 (14.30–34.18)	0.27^‡
Change	0.91 (−6.88–12.37)	4.90 (−11.34–11.66)	0.58^‡
RRR
Pre-PCI	3.26 (1.86–4.15)	2.75 (2.04–4.31)	0.94^‡
Post-PCI	4.25 (2.45–5.24)	2.75 (1.67–3.44)	<0.01^‡
Change	1.05 (−0.91–2.64)	−0.09 (−1.34–0.88)	0.054^‡
Laboratory results
hs-troponin-I (ng/L)
Pre-PCI	9 (3–769)	13 (3–93)	0.88^‡
Post-PCI	184 (60–643)	259 (139–779)	0.55^‡
Absolute change	46 (1–154)	152 (48–633)	0.01^‡
WBC count
Pre-PCI	6.7 ± 1.3	7.7 ± 1.5	0.02^†
Post-PCI	7.6 ± 1.6	8.5 ± 1.7	0.06^†
Change	0.9 ± 1.6	0.8 ± 1.0	0.84^†
Neutrophil count
Pre-PCI	4.0 ± 1.1	4.7 ± 1.3	0.06^†
Post-PCI	4.7 ± 1.1	5.6 ± 1.4	0.02^†
Change	0.6 ± 1.3	0.9 ± 1.0	0.48^†
hsCRP (mg/L)
Pre-PCI	1.1 (0.5–5.7)	1.1 (0.6–4.3)	0.78^‡
Post-PCI	1.0 (0.5–5.9)	1.7 (0.8–2.7)	0.97^‡
Change	0.0 (−0.1–0.1)	0.2 (0.0–0.4)	0.21^‡

Values are mean ± SD or median (LQ-UQ), denotes comparison between colchicine vs placebo group, † denotes independent-samples t-test, and ‡ denotes Mann–Whitney U test.