Congenital heart disease (CHD) is one of the most common types of birth defects. Its complexity and severity make it one of the main causes of perinatal morbidity and mortality. Thus, the appropriate diagnosis and treatment of perinatal CHD may be essential to improving the prognosis of CHD. Recently, the integration of prenatal diagnosis-postpartum treatment of CHD is becoming more and more important. The perinatal diagnosis of CHD mainly depends on imaging examinations, including fetal echocardiography and magnetic resonance imaging (MRI), and with the development of imaging technology, the time of perinatal diagnosis of CHD has advanced to first-trimester. Thus, treatments of perinatal CHD have also made some progress. The treatments of perinatal CHD mainly include cardiac surgery and endovascular treatments. The latter treatments include intrauterine fetal cardiac intervention (FCI), neonatal intervention, and childhood intervention. The application of endovascular treatments has great impact on improving the prognosis of perinatal CHD. For example, intrauterine FCI has become a mature therapy in some specific types of perinatal CHD, such as pulmonary atresia with an intact ventricular septum (PA/IVS) and critical pulmonary stenosis (CPS). A study reported that its success rate is about 70% according to 33 cases of pulmonary FCI around world. Additionally, another study found half of the neonates with fetal CHD benefited from an urgent intervention at birth. Thus, the endovascular treatment of perinatal CHD is a hot topic of research.

In this special issue, we aim to update the current knowledge of endovascular treatment for perinatal CHD. We encourage both basic and clinical investigators to contribute original research articles, particularly focusing on prenatal and newborn novel techniques in the endovascular treatment for perinatal CHD. We also welcome review articles and meta-analysis that describe the current state of this field.

Potential topics include but are not limited to the following:

• The endovascular treatment of perinatal CHD at different stages, including in the antenatal, neonatal, and childhood period
• Advancements in intrauterine fetal cardiac intervention
• Indications and contraindications of endovascular treatment about different perinatal CHDs
• The advantages and disadvantages of endovascular treatment compared with traditional surgery of perinatal CHD
• The outcome and prognosis of the endovascular treatment of perinatal CHD