Review Article

Lipidomics: The Function of Vital Lipids in Embryogenesis Preventing Autism Spectrum Disorders, Treating Sterile Inflammatory Diatheses with a Lymphopoietic Central Nervous System Component

Table 2

Biological dietary treatment for various sterile inflammatory diatheses.

In cancer studies based on a combined biological and specific stimulation of the patients immunity to autologous tumour markers (bioimmunotherapy) a lymphopoietic central nervous system lipid (CNS) component was found to be crucial for normal white cell function [1]. A deficiency in this vital CNS-lipid component can also cause aberrant inflammatory reactions, as in Inflammatory bowel disease (IBD), and in several other related sterile inflammatory diatheses e.g., crohn’s disease polyarthritis. This CNS lipidfactor, containing titanium (Ti), is essential for a normal immune response (as a collateral to the cobalt in B12 for erythropoiesis). The high and soaring incidence of these sterile inflammatory diseases is causing a major general health problem while lacking effective curative treatments. In bioimmunotherapy for colon cancer, since the seventies, the precancerous Crohn’s disease (CD), and ulcerative colitis (UC) were found to be alleviated and cured following specific dietary supplementation. The aim was therefore to try to delineate these nutritive factors and to uncover effective, sustainable biological treatment modalities for these diverse chronic sterile inflammatory diatheses since they are potentially precancerous, like any chronic inflammation.

Nutritional supplementation acting as functional foods, containing a physiologic combination of: certain amino-acids, trace-element ions, vital central nervous system (CNS) lipids, the lymphopoietic lipid component containing Ti, plus physiologic amounts of vitamins, especially B12 were, fed as ready-made powders, to improve patient compliance, in preliminary therapeutic trials for; CD, UC, fibromyalgia (FbM), rheumatism (Rh) lacking increased Rh factor, psoriasis (PSO), polyarthritis (PyA), periosteal bone pain (PP), pancreatitis (PaC), Reiters disease (RD), and so forth.

These aberrant inflammatory reactions could in certain patients be alleviated by nutritional biotherapy administering-specific aminoacids (2–5 g/d) mixed with trace-element ions; Cr, Mn, Rb, Se, Sr, V, W (1.5–2.5 mg/d) and CNS-lipids, with assorted fruits as a tasty blend, easily prepared using canned healthy prion-free brain lipids, produced by Neurofood Ltd. Finland. Canned brain containing 220 g is sufficient for two weeks as a dietary supplement furnishing the essential CNS lipids our healthy body requires. The dietary supplement of amino acids required is Leu, Lys, Arg, and also Gly, Glu, (to prevent splitting of the glutathione in the leukotriene molecule by γ-GT into Glu, and Gly whereby γ-GT is inhibited (also by boron). This results in substrate inhibition and can thus prevent the leukotriene-cascade cycle causing sterile inflammatory lesions, expressed as increased capillary permeability, and formation of the slow-acting substance of anaphylaxis. These organic and inorganic alimentary supplements ingested in addition with 220 g of CNS lipid molecules (every second week) have caused a positive clinical response. Dietary supplements could mitigate symptoms of CD in some weeks, and the clinical effect could be sustained for years. Biotherapy for UC is principally linked to the same dietary formulation, with the further addition of, Asp Ile, Ser, Thr, (5 g/d), + Mo, Se, and W (1.5–2.5 mg/d) + CNS-lipids. For FbM mainly, Gly, Glu, Leu, Arg, + all trace-element ions mentioned, and CNS-lipids mixed in fruits for the sake of taste; for Rh, Ala, Ile, Leu, Ser, The trace-element ions, + CNS-lipids. For PSO especially Ile, Gly, Glu + Tinn (Sn) and CNS-lipids. In PYA, PP, supplying especially strontium (Sr) and serine (L-Ser) is essential to keep bone membranes (periost) healthy. PaC requires a lowering of serum phospholipase-A activity. This can be achieved by chelation of the serum calcium ions, which activates this lipidsplitting enzyme, involved in causing pancreatitis.

Beneficial nutritional clinical therapy for these diverse premalignant diatheses is dependent on normalization of the immunesystem in patients by ingesting this lymphopoietic CNS-lipid component (forming the functional “lipidome” based on billions of vital CNS-lipid molecules) acting in concert with certain essential amino acids and trace-element ions regulating healthy cell induction. Dietary supplementation is curative inexpensive, and causes no sideeffects.