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Journal of Lipids
Volume 2011, Article ID 167958, 13 pages
http://dx.doi.org/10.1155/2011/167958
Research Article

Protective Effects of Simvastatin, a Lipid Lowering Agent, against Oxidative Damage in Experimental Diabetic Rats

1Department of Chemistry for Health Sciences, Deanery of Academic Services, Health Sciences Track, Taibah University, Al-Madinah, Saudi Arabia
2Biochemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt
3Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia
4Department of Physiology, College of Medicine, Taibah University, Al-Madinah, Saudi Arabia
5Biochemistry Department, Applied Science College, Taibah University, Al-Madinah, Saudi Arabia
6Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

Received 5 May 2011; Revised 16 July 2011; Accepted 12 September 2011

Academic Editor: Robert Salomon

Copyright © 2011 Ahmed M. Mohamadin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study was undertaken to evaluate the possible protective effects of simvastatin (SMV) against oxidative stress in streptozotocin- (STZ)-induced diabetic rats. Diabetes was induced experimentally in rats by i.p. injection of STZ in a dose of 60 mg/kg bwt. After 5 weeks of STZ injection, there were apparent reductions in the animal body weight and significant increase in blood glucose, HbA1c, urea, creatinine, AST, ALT, and lipid profiles with a concomitant decrease in total hemoglobin, plasma glutathione and vitamin C as compared to the control group. The treatment with SMV at a dose (10 mg/kg, orally) normalized all the above-mentioned biochemical parameters in STZ-induced diabetic rats. In vitro studies confirmed the free radical scavenging and antioxidant activity of SMV. Therefore, the present results revealed that SMV has a protective effect against STZ-induced oxidative damage by scavenging the free radicals generation and restoring the enzymatic and nonenzymatic antioxidant systems.