Temporal changes in plasma OxLDL levels and atherogenesis in apoE-KO mice. Male apoE-KO mice were maintained on normal diet up to 40 weeks. The atherosclerotic lesion on the aortic surface increased sharply after 20 weeks. Plasma OxLDL levels increased at 20 weeks just before the lesions began growing. The plasma OxLDL levels seem to decrease concomitantly with an increase in the size of the lesion (cited from [41] with modification).
