LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes
Figure 6
LysoPC-mediated [3H]AA release is inhibited by the PAF-receptor antagonist WEB2170. Prelabeled THP-1 cells were preincubated with WEB2170, stimulated with (a) lysoPC (40 μM, 10 min.) or (b) PAF (35 μM, 5 min) and [3H]AA release in the medium was measured by liquid scintillation counting. Data are expressed as means ± SD of triplicate determinations within separate experiments. Asterisks indicate that values are statistically different from PAF- or lysoPC-treated cells (*).
