Remodelling of Membrane Rafts Expression in Lung Cells as an Early Sign of Mechanotransduction-Signalling in Pulmonary Edema

Figure 7

Possible model of lung cellular response to an increase in interstitial pressure caused by an increase in extravascular water not exceeding 5–10% (interstitial edema). Cell signaling is activated by mechanical stimulation through rigid links (collagen I, B-integrin, cytoskeleton), chemical/mechanical activation of the MRs by fragments of matrix and basement membrane (perlecan, versican, resp.). The activation of ASMase leads to ceramide formation that modulates different intracellular signaling pathways.