Journal of Lipids / 2011 / Article / Tab 4

Research Article

Hydroxyurea Therapy Mobilises Arachidonic Acid from Inner Cell Membrane Aminophospholipids in Patients with Homozygous Sickle Cell Disease

Table 4

Fatty acid composition of red blood cell sphingomyelin of HU-untreated ( ) and treated ( ) HbSS patients and HbAA healthy controls ( ).

Fatty acidsHbSS (untreated)HbSS (treated)HbAA (healthy control)

16:021.1 ± 4.3*25.3 ± 3.526.1 ± 2.2++
18:08.7 ± 2.2*11.9 ± 3.511.3 ± 2.0++
20:02.0 ± 0.21.00 ± 0.2×××1.44 ± 0.2+++
22:08.1 ± 1.5*6.6 ± 1.37.6 ± 1.1
24:025.3 ± 4.8***18.5 ± 2.9××21.6 ± 2.6+
saturates63.9 ± 3.863.8 ± 3.1×××68.2 ± 1.4++

16:1n-7tr.tr.tr.
18:1n-70.3 ± 0.1***0.7 ± 0.1××0.5 ± 0.1+++
18:1n-93.8 ± 1.93.4 ± 0.6×××2.0 ± 0.3++
24:1n-917.8 ± 3.6**14.2 ± 1.713.9 ± 1.7++
monoenes21.9 ± 2.8***18.3 ± 2.0×16.5 ± 1.8+++

18:2n-62.1 ± 1.12.3 ± 0.62.0 ± 0.3
18:3n-6tr.tr.tr.
20:2n-60.4 ± 0.3**0.1 ± 0.04××0.09 ± 0.04++
20:3n-60.3 ± 0.1**0.5 ± 0.1××0.3 ± 0.1
20:4n-63.7 ± 1.3*4.9 ± 15.1 ± 1.3++
22:4n-61.8 ± 1.02.0 ± 0.8×1.3 ± 0.4
22:5n-61.4 ± 0.61.3 ± 0.61.1 ± 0.3
metabolites7.5 ± 2.98.4 ± 1.97.9 ± 2.1
n-69.6 ± 3.510.8 ± 1.7 9.9 ± 2.2

18:3n-3tr.tr.tr.
20:5n-30.11 ± 0.02***0.07 ± 0.020.06 ± 0.02+++
22:5n-30.4 ± 0.20.45 ± 0.20.4 ± 0.1
22:6n-31.4 ± 0.71.8 ± 0.81.7 ± 0.6
metabolites1.9 ± 0.82.4 ± 0.92.1 ± 0.7
n-31.9 ± 0.82.4 ± 0.92.1 ± 0.7

N6/N35.3 ± 1.65.3 ± 1.74.9 ± 1.1

tr.: trace.
HU-untreated versus treated HbSS patients: * , ** , *** .
HU-untreated HbSS patients versus HbAA healthy controls: + , ++ , +++ .
HU-treated HbSS patients versus HbAA healthy controls: × , ×× , ××× .