Research Article

Novel Associations of Nonstructural Loci with Paraoxonase Activity

Table 1

Proportion of variance explained by covariates. The proportion of variation explained by each significant variable was calculated for the three substrates by adding each to a polygenic model in SOLAR.

Variation explained

CovariatePON1-arylPON1-lactPON1-para
Sex0.4%0.0%0.4%
Age1.1%1.4%0.4%
Age21.1%1.9%0.1%
Sex*age0.7%0.4%0.7%
192QR3.9%8.3%36.5%
55LM5.7%4.1%13.9%
rs8545222.7%1.8%1.1%
rs8545343.4%3.8%2.1%
rs75715811.5%9.2%4.1%
rs78031480.9%1.1%0.6%