A Pleiotropic Role for the Orphan Nuclear Receptor Small Heterodimer Partner in Lipid Homeostasis and Metabolic Pathways
Schematic diagram of the function and gene regulation of SHP. Different conditions will lead to activation of nuclear receptors and/or transcription factors able to regulate Shp gene expression in the nucleus and protein synthesis in the cytoplasm. The protein acts as a transcriptional corepressor of a number of other nuclear receptors and transcription factors involved in a wide series of regulatory pathways. The potential role of a feedback mechanism and of ligand(s) is hypothesized.
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