Journal of Lipids / 2012 / Article / Fig 4

Review Article

A Pleiotropic Role for the Orphan Nuclear Receptor Small Heterodimer Partner in Lipid Homeostasis and Metabolic Pathways

Figure 4

Schematic diagram of the function and gene regulation of SHP. Different conditions will lead to activation of nuclear receptors and/or transcription factors able to regulate Shp gene expression in the nucleus and protein synthesis in the cytoplasm. The protein acts as a transcriptional corepressor of a number of other nuclear receptors and transcription factors involved in a wide series of regulatory pathways. The potential role of a feedback mechanism and of ligand(s) is hypothesized.

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