Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer

Table 1

Expression levels of PON2 in various tumor tissues and/or cancer cell cultures. Microarray experiment (array express) listings are according to the Gene Atlas Database. Protein and cDNA levels according to [23]. Cell culture expression levels were roughly estimated as relative level comparing to A549, grouped into low, medium, or high.

Tissue (cancer)	Protein level (fold of normal tissue)	cDNA array (fold of normal tissue)	Microarray studies	Cell culture (expression level in cell line)
Kidney	2	2.2	Upregulated in renal carcinoma (E-MTAB-37)	Medium (HEK293)
Liver	1.7	2.2	Overexpressed (Li et al. [15])	High (Huh7/HepG2)
Lung	1.3	1	Upregulated in lung adenocarcinoma (E-MEXP-231/E-MTAB-37) Downregulated in small cell lung carcinoma (E-GEOD-4127)	High (A549; H661; H1299)
Spleen	0.5	n/a
Pancreas	1.4	1.6	Upregulated in pancreatic carcinoma (E-MTAB-37)
Thymus	11.5	n/a
Urinary bladder	n/a	4.1		High (HT1367/RT112)
Esophagus	n/a	0.6	Upregulated in esophageal cancer (E-MTAB-62)
Stomach	n/a	1	Upregulated in gastric carcinoma (E-GEOD-2685)
Ovar	n/a	1	Upregulated (E-MTAB-62)
Cervix	n/a	1	Upregulated (E-MTAB-37/E-MTAB-62)	Medium (HeLa)
Adrenal gland	n/a	1	Downregulated in adrenocortical carcinoma (E-TABM-311)
Thyroid gland	n/a	1.4	Upregulated (E-GEOD-3467/E-GEOD-3678)
Prostate	n/a	1.6	Overexpressed (Ribarska, T. et al. [16] E-MTAB-62)
Testis	n/a	1.7		Low (SuSa/GCT27/833K)
Uterus/endometrium	n/a	2.1
Lymphoid tissue	n/a	2.5
Leukemias (various)	n/a		Upregulated in pediatric ALL (Ross et al. and Kang et al. [17, 18])	Low in AML-like Nalm6/EOL; Jurkat Tcells; PML-like HL60/HCW2; CML-like KCL Medium in blast crisis line K562; CML-like lama; AML-like THP1/MonoMac6/HEL
Non-Hodgkin	11.9	n/a	Downregulated (E-MTAB-37)