Research Article

Molecular Characterization of Lipopolysaccharide Binding to Human α-1-Acid Glycoprotein

Figure 4

Molecular model of the Kdo2-lipid A F1*S AGP complex. (a) The AGP F1*S variant crystal structure (PDB code: 3KQ0) is shown in semitransparent surface representation, the bound Kdo2-lipid A is shown in CPK, carbon is colored blue. The Kdo2-lipid A and quaternary N-glycans on the AGP structure are indicated schematically (○ Man; □ GlcNAc; ⚫  D-Gal) and are shown in ball- and stick-representation on the model. (b) Interactions between the fatty acyl chains of lipid A and the side chains of the ligand binding cavity of AGP.