Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease

Table 2

Best-fit model from stepwise linear regression predicting PON1 AREase activity.

Variable	Coefficient (± SE)	Gene^a	MAF^b	t-statistic^c	AREase Variation %	P
(Intercept)	284.09(±13.99)	—	—	20.304	—	< 2.0 × 10^−16
PON1C-108T	−24.82(±2.61)	(PON1)	0.43	−9.498	14.10%	< 2.0 × 10^−16
PON1G-162A	4.61(±4.60)	(PON1)	0.18	1.002	0.21%	0.317
PON1Q192R	−22.09(±4.20)	PON1	0.33	−5.258	1.17%	1.8 × 10^−7
PON1M55L	−7.05(±3.64)	PON1	0.42	−1.94	1.01%	0.053
Age	−1.33(±0.15)	—	—	−9.014	4.29%	< 2.0 × 10^−16
Current smoker	−28.25(±3.63)	—	—	−7.776	4.42%	1.95 × 10^−14
rs854567	−8.19(±4.77)	(PON1)	A = 0.185	−1.719	2.34%	0.086
rs2299257	12.66(±3.57)	(PON1)	C = 0.391	3.546	0.85%	4.11 × 10^−4
rs2237583	11.36(±3.12)	(PON1)	A = 0.284	3.645	0.5%	2.82 × 10^−4
rs2375005	−8.32(±2.56)	(PON2)	T = 0.462	−3.25	0.34%	0.001
rs3917486	14.91(±4.97)	(PON1)	A = 0.054	2.998	0.58%	0.003
rs11768074	8.42(±4.48)	(PON3)	A = 0.157	1.878	0.26%	0.061

SE = standard error, MAF = minor allele frequency.
^aNoncoding SNPs are presented in parentheses, for example, (PON1).
^bMinor allele frequencies for the four functional SNPs reported through dbSNP. The remaining minor allele frequencies were calculated via the CLEAR cohort.
^ct-statistics and 𝑃 values were calculated from the coefficients (from all subjects) and standard errors within the best-fit multivariate model by the glm function in R.