Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity

Table 2

Atherogenic and antiatherogenic elements in the plaques and blood of symptomatic and asymptomatic patients.

		Symptomatic (𝑛=6)	Asymptomatic (𝑛=13)	P value
Plaque	PON lactonase activity (U/mg proteins)	0.16±0.035  (𝑛=8)	0.18±0.054 (𝑛=9)	N.S.
	Triglyceride (% of LLE)	3.4±1.07	2.37±0.37	N.S.
	7-keto (% of cholesterol)	0.38±0.19	0.25±0.05	N.S.
	26-OH (% of cholesterol)	1.16±0.27	1.29±0.19	N.S.
	7α-OH (% of cholesterol)	0.087±0.015	0.085±0.01	N.S.
	7β-OH (% of cholesterol)	0.075±0.01	0.08±0.009	N.S.
	β-epoxy (% of cholesterol)	0.096±0.01	0.114±0.02	N.S.
	α-epoxy (% of cholesterol)	0.055±0.004	0.069±0.008	N.S.
	LA-13OOH (μg/mg plaque)	0.012±0.002	0.0053±0.0009	0.019
Serum	PON1 lactonase activity (U/mL)	38±3.2	45±2.9	N.S.
	HbA1c (%)	7.17±0.48	6.04±0.15	0.065
	HDL (mg/dL)	37.8±3.35	51.7±3.06	0.009
	LDL (mg/dL)	79±13.2	90.9±4.4	N.S.
	Cholesterol (mg/dL)	158.6±11.2	168.08±6.4	N.S.
	Triglyceride (mg/dL)	164.8±27	127.2±15.2	N.S.

LLE: lesion lipid extract. Results are presented as mean ± SEM.