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Journal of Lipids
Volume 2013 (2013), Article ID 129736, 7 pages
Research Article

Analgesic, Anti-Inflammatory and Anticancer Activities of Extra Virgin Olive Oil

1Laboratoire de Biosurveillance de l'Environnement (LR01/ES14), Equipe REMP “Risque Écologique des Médicaments & Pesticides”, Faculté des Sciences de Bizerte, Université de Carthage, 7021 Zarzouna, Tunisia
2INSERM, U848, 94805 Villejuif, France
3Institut Gustave Roussy, 94805 Villejuif, France
4CNRS UMR5237, CRBM 1919 Route de Mende, 34293 Montpellier, France

Received 20 May 2013; Revised 10 October 2013; Accepted 24 October 2013

Academic Editor: Maurizio Averna

Copyright © 2013 Myriam Fezai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. In folk medicine, extra virgin olive oil (EVOO) is used as a remedy for a variety of diseases. This study investigates the in vivo antinociceptive, anti-inflammatory, and anti-cancer effects of EVOO on mice and rats. Materials and Methods. In this experimental study, using the acetic acid-induced writhing and formalin tests in mice, the analgesic effect of EVOO was evaluated. Acetylsalicylic acid and morphine were used as standard drugs, respectively. The anti-inflammatory activity was investigated by means of the carrageenan-induced paw edema model in rats using acetylsalicylic acid and dexamethasone as standard drugs. Last, the xenograft model in athymic mice was used to evaluate the anticancer effect in vivo. Results. EVOO significantly decreased acetic acid-induced abdominal writhes and reduces acute and inflammatory pain in the two phases of the formalin test. It has also a better effect than Dexamethasone in the anti-inflammatory test. Finally, the intraperitoneal administration of EVOO affects the growth of HCT 116 tumours xenografted in athymic mice. Conclusion. EVOO has a significant analgesic, anti-inflammatory, and anticancer properties. However, further detailed studies are required to determine the active component responsible for these effects and mechanism pathway.