Grape Seed Proanthocyanidin Rescues Rats from Steatosis: A Comparative and Combination Study with Metformin
Figure 8
Histology of liver stained using hematoxylin and eosin. Section from control liver (a) and CON + GSP (f) shows hepatocytes within normal architecture arranged in the lobules around the central vein. Liver of HFFD-fed rats (b) shows severe micro- and macrovesicular changes and dense perivascular inflammatory infiltrate. HFFD + GSP show minimal inflammatory infiltrate with mild steatosis (c). Liver section from HFFD + MET (d) shows moderate amount of inflammatory infiltrate with microvesicular degeneration of hepatocytes. Section from the liver of HFFD + GSP + MET (e) shows hepatocytes with marked reduction of inflammation and steatosis. (Black arrows indicate steatosis and the yellow arrows indicate inflammation.)
