Roles of Fatty Acid Oversupply and Impaired Oxidation in Lipid Accumulation in Tissues of Obese Rats

Table 3

𝐾^∗_𝑓 and 𝐾_𝑓𝑠 in individual hind leg muscles in vivo in lean and obese Zucker rats.

	𝐾^∗𝑓 (mL 100 g^−1 min^−1)				𝐾𝑓𝑠 (mL 100 g^−1 min^−1)
	Lean		Obese		Lean		Obese
	Con-Leg	Stim-Leg	Con-Leg	Stim-Leg	Con-Leg	Stim-Leg	Con-Leg	Stim-Leg
WG	0.76±0.06	2.03±0.23^†	0.69±0.04	1.86±0.10^†	1.87±0.16	2.54±0.12^†	1.96±0.18	2.35±0.14
EDL	1.08±0.08	3.38±0.21^†	1.06±0.08	2.54±0.21^†∗	3.32±0.31	4.26±0.21^†	4.26±0.44	4.65±0.23
RG	1.17±0.07	2.58±0.47^†	1.39±0.11	2.10±0.17^†	3.75±0.23	5.08±0.46^†	4.48±0.44	6.37±0.54^†
WQ	0.61±0.05	0.66±0.07	0.51±0.02	0.52±0.03	1.39±0.10	1.42±0.12	1.17±0.06	1.16±0.06
RQ	1.63±0.13	1.54±0.13	1.86±0.13	1.76±0.12	4.28±0.38	4.06±0.30	4.56±0.21	4.14±0.23

Sustained twitch contractions were induced in the lower leg muscles (WG white gastrocnemius, EDL extensor digitorum longus, and RG red gastrocnemius) but not in the upper leg muscles (WQ white quadriceps and RQ red quadriceps) by repetitive electrical stimulation of the sciatic nerve of one leg (Stim-Leg). The contralateral, control leg (Con-Leg) was not subjected to sciatic nerve stimulation. Results represent mean ± SEM (𝑛=6 per group). ^†𝑃<0.05 versus Con-Leg (paired 𝑡-test, effect of sciatic nerve stimulation), ^∗𝑃<0.05 versus Lean (unpaired 𝑡-test, effect of obesity status).