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Journal of Lipids
Volume 2013, Article ID 684903, 8 pages
Review Article

High-Density Lipoproteins and the Immune System

Division of Physiology and Metabolism, University of Hyogo, 13-71 Kitaohji-cho, Akashi 673-8588, Japan

Received 5 October 2012; Revised 28 December 2012; Accepted 31 December 2012

Academic Editor: Maurizio Averna

Copyright © 2013 Hidesuke Kaji. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


High-density lipoprotein (HDL) plays a major role in vasodilation and in the reduction of low-density lipoprotein (LDL) oxidation, inflammation, apoptosis, thrombosis, and infection; however, HDL is now less functional in these roles under certain conditions. This paper focuses on HDL, its anti-inflammation behavior, and the mechanisms by which HDL interacts with components of the innate and adaptive immune systems. Genome-wide association studies (GWAS) and proteomic studies have elucidated important molecules involved in the interaction between HDL and the immune system. An understanding of these mechanisms is expected to be useful for the prevention and treatment of chronic inflammation due to metabolic syndrome, atherosclerosis, or various autoimmune diseases.