Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPAR𝜸 Signaling and Inflammation in Murine Mammary Tissue

Table 3

Top canonical pathways (FDR = 0.2, 𝑃<0.001, and fold change >1.5) from IPA analysis of DEG in mammary tissue of lactating mice fed trans-10, cis-12-CLA.

Canonical pathways	−log (𝑃 value)	Downregulated^1	Upregulated^1
Acute-phase response signaling	1.88𝐸+00	81/178 (46%)	73/178 (41%)
Regulation of actin-based motility by rho	1.60𝐸+00	38/92 (41%)	39/92 (42%)
Glycosphingolipid biosynthesis-Ganglio series	1.54𝐸+00	10/58 (17%)	11/58 (19%)
RAR activation	1.51𝐸+00	78/187 (42%)	74/187 (40%)
LXR/RXR activation	1.44𝐸+00	32/86 (37%)	32/86 (37%)

 ¹Fisher’s exact test was used to calculate a 𝑃 value determining the probability that the association between the genes in the dataset and the canonical pathway is explained by chance alone.