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  1. B. S. Peskin, “Why fish oil fails: a comprehensive 21st century lipids-based physiologic analysis,” Journal of Lipids, vol. 2014, Article ID 495761, 15 pages, 2014.
Journal of Lipids
Volume 2014 (2014), Article ID 495761, 15 pages
Review Article

Why Fish Oil Fails: A Comprehensive 21st Century Lipids-Based Physiologic Analysis

The International PEO Society, P.O. Box 56507, Houston, TX 77256, USA

Received 26 September 2013; Revised 10 November 2013; Accepted 11 November 2013; Published 16 January 2014

Academic Editor: Angel Catalá

Copyright © 2014 B. S. Peskin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The medical community suffered three significant fish oil failures/setbacks in 2013. Claims that fish oil’s EPA/DHA would stop the progression of heart disease were crushed when The Risk and Prevention Study Collaborative Group (Italy) released a conclusive negative finding regarding fish oil for those patients with high risk factors but no previous myocardial infarction. Fish oil failed in all measures of CVD prevention—both primary and secondary. Another major 2013 setback occurred when fish oil’s DHA was shown to significantly increase prostate cancer in men, in particular, high-grade prostate cancer, in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) analysis by Brasky et al. Another monumental failure occurred in 2013 whereby fish oil’s EPA/DHA failed to improve macular degeneration. In 2010, fish oil’s EPA/DHA failed to help Alzheimer’s victims, even those with low DHA levels. These are by no means isolated failures. The promise of fish oil and its so-called active ingredients EPA / DHA fails time and time again in clinical trials. This lipids-based physiologic review will explain precisely why there should have never been expectation for success. This review will focus on underpublicized lipid science with a focus on physiology.