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Journal of Lipids
Volume 2014, Article ID 546863, 7 pages
Research Article

Comparison of Carotid Intima-Media Thickness in Pediatric Patients with Metabolic Syndrome, Heterozygous Familial Hyperlipidemia and Normals

1Emory University Hospital Radiology, Atlanta, GA 30322, USA
2University of Arizona College of Medicine, Tucson, AZ 85724, USA

Received 31 January 2014; Revised 17 April 2014; Accepted 22 April 2014; Published 14 May 2014

Academic Editor: Gerhard M. Kostner

Copyright © 2014 Arvind Vijayasarathi and Stanley J. Goldberg. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Our goal was to compare the carotid intimal-medial thickness (CIMT) of untreated pediatric patients with metabolic syndrome (MS), heterozygous familial hyperlipidemia (heFH), and MS+heFH against one another and against a control group consisting of healthy, normal body habitus children. Methods. Our population consisted of untreated pediatric patients (ages 5–20 yrs) who had CIMT measured in a standardized manner. Results. Our population included 57 with MS, 23 with heFH, and 10 with MS+heFH. The control group consisted of 84 children of the same age range. Mean CIMT for the MS group was 469.8 μm (SD = 67), 443.8 μm (SD = 61) for the heFH group, 478.3 μm (SD = 70) for the MS+heFH group, and 423.2 μm (SD = 45) for the normal control group. Significance differences between groups occurred for heFH versus MS , heFH versus control , MS versus control , and MS+heFH versus control . Analysis showed significant negative correlation between HDL and CIMT but not for LDL, triglycerides, BP, waist circumference, or BMI. Conclusion. For pediatric patients, the thickest CIMT occurred for patients with MS alone or for those with MS+heFH. This indicates that MS, rather than just elevated LDL, accounts for more rapid thickening of CIMT in this population.