Role of Inositol Phosphosphingolipid Phospholipase C1, the Yeast Homolog of Neutral Sphingomyelinases in DNA Damage Response and Diseases

Figure 1

The flow diagram represents the sphingolipid metabolism pathways both in mammals and in yeast. The common steps in both the organisms are shown in yellow boxes. The yeast sphingolipid metabolism pathway steps are shown in red boxes while mammals pathway are shown in green boxes; the positions of sphingomyelinase (SMase) and inositol phosphosphingolipid phospholipase C1 (ISC1) are shown in green and red letters, respectively.