Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality

Table 4

Summary of the main findings.

ApoE2/4 lipid/lipoprotein level (or risk) compared to
	ApoE 2/2	ApoE 2/3	ApoE 3/3	ApoE 3/4	ApoE 4/4
TG	Lower	—	Higher	—	—
Total C	—	—	—	—	—
LDL-C	Higher^1	—	—	—	—
HDL-C	—	—	—	—	—
VLDL-C	Lower	—	—	—	—
VLDL-TG	Lower	—	—	—	—
LDL-TG	—	—	—	—	—
HDL-TG	—	—	—	—	—
Total ApoB	Higher	—	—	—	—
TG > 1.7 mmol/L	Lower	—	Higher	—	—
LDL-C > 3.4	—	—	Higher	—	Lower
HDL-C < 0.9 mmol/L	—	—	—	—	—
Non-HDL-C > 4.2 mmol/L	—	—	—	—	Lower
Total C/HDL-C. > 5	—	Higher	Higher	—	—
VLDL-C/TG > 0.5	Lower	—	Higher	Higher	—

Present is a summary of the lipid/lipoprotein differences between ApoE2/4 carriers and the other genotypes. Lower means that ApoE2/4 carriers present a lower level (or risk) than the selected genotype while higher means that ApoE2/4 carriers present a higher level (or risk) than the selected genotype. This summary is based on Table 2 and Figures 1 and 2.
Note: ApoB: apolipoprotein B-100 measured on delipidated plasma; C: cholesterol; HDL: high-density lipoprotein; LDL: low-density lipoprotein; TG: triglycerides
¹The difference between ApoE2/2 and ApoE2/4 for LDL-C only reached significance when measured after ultracentrifugation.