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Journal of Lipids
Volume 2016, Article ID 7498508, 9 pages
http://dx.doi.org/10.1155/2016/7498508
Research Article

8-Hydroxyeicosapentaenoic Acid Decreases Plasma and Hepatic Triglycerides via Activation of Peroxisome Proliferator-Activated Receptor Alpha in High-Fat Diet-Induced Obese Mice

1Iwate Biotechnology Research Center, 22-174-4 Narita, Kitakami, Iwate 024-0003, Japan
2Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa, Iwate 028-3694, Japan

Received 28 October 2015; Revised 16 March 2016; Accepted 29 March 2016

Academic Editor: Rosemary Lee Walzem

Copyright © 2016 Hidetoshi Yamada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Experimental design (Figure S1, S2), compositions of the diets (Table S1), primers for real-time PCR (Table S2), concentration of plasma 8-HEPE in mice (Table S3), concentration of plasma adiponectin and leptin in mice (Table S4), hepatic gene expression changes (Figure S3, S4) and Muscle Angptl4 gene expression change (Figure S5) are shown in supplemental material.

  1. Supplementary Material