Developing a Modified Low-Density Lipoprotein (M-LDL-C) Friedewald’s Equation as a Substitute for Direct LDL-C Measure in a Ghanaian Population: A Comparative Study

Table 4

Diagnosis performances of the various formulas.

Formulas	Cut-off point	AUC	95 CI	Sensitivity (95 CI)	Specificity (95CI)	NPV	PPV
F-LDL-C	2.92	0.80	0.78-.83	0.63(0.60-0.67)	0.84(0.82-0.87)	0.87	0.74
N-LDL-C	2.92	0.81	0.78-.83	0.63(0.60-0.66)	0.85(0.82-0.87)	0.87	0.78
A-LDL-C	2.96	0.77	.75-.78	0.68(0.65-0.72)	0.73(0.70-0.77)	0.68	0.73
M-LDL-C	3.23	0.81	.78-.83	0.60(0.56-0.64)	0.88(0.85-0.90)	0.72	0.72

AUC: area under curve; CI: confidence interval; NPV: negative predictive value; PPV: positive predictive value; FLDL-C, LDL-C calculated by Friedewald’s formula; N-LDL-C, LDL-C calculated by Martin’s formula; A-LDL-C, LDL-C calculated by Anandaraja’s formula; M-LDL-C, LDL-C calculated by modified formula.