Journal of Lipids / 2019 / Article / Tab 2 / Research Article
Apolipoprotein E2 Genotype Is Associated with a 2-Fold Increase in the Incidence of Type 2 Diabetes Mellitus: Results from a Long-Term Observational Study Table 2 Baseline characteristics of the 436 patients with different APOE alleles.
APOE2 carriers APOE3 homozygotes APOE4 carriers p value(N=51) (N=283) (N=102) Age – years 53±13 50±14 44±15 <0.001 Male – no. (%) 32 (62.7) 163 (57.6) 60 (58.4) 0.79 Weight – kg 79±9 77±14 76±14 0.51 SBP – mmHg 135 (125-150) 135 (122-146) 126 (115-140) 0.16 DBP – mmHg 88 (80-90) 80 (76-90) 80 (70-90) 0.09 TC – mmol.L−1 6.8 (5.7-8.5) 7.0 (6.0-8.2) 6.9 (5.9-7.9) 0.53 HDL cholesterol – mmol.L−1 1.1 (1.0-1.4) 1.2 (1.0-1.5) 1.2 (0.9-1.5) 0.46 LDL cholesterol – mmol.L−1 3.3 (2.6-4.5) 4.1 (3.0-4.9) 4.0 (3.0-5.3) 0.04 Lp(a) – mmol.L−1 0.36 (0.13-0.93) 0.39 (0.16-0.96) 0.36 (0.16-0.96) 0.94 ApoE – mmol.L−1 0.20 (0.15-0.33) 0.14 (0.11-0.18) 0.11 (0.09-0.16) <0.001 ApoB – mmol.L−1 3.1 (2.4-3.7) 3.8 (3.1-4.5) 3.5 (3.0-3.9) <0.001 ApoA – mmol.L−1 3.8 (3.2-4.4) 4.0 (3.5-4.6) 3.8 (3.2-4.4) 0.28 ApoB/ApoA 0.8 (0.6-1.0) 1.0 (0.7-1.2) 0.9 (.8-1.1) 0.10 Triglycerides – mmol.L−1 8.7 (5.5-13.5) 5.2 (3.2-8.8) 4.5 (2.8-11.0) <0.001 Serum creatinine – µ mol.L−1 68.6 (68.6 -76.3) 68.6 (61.0-76.3) 68.6 (61.0-76.3) 0.65
APOE: apolipoprotein E; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; LDL: low-density lipoprotein; HDL: high-density lipoprotein; Lp(a): lipoprotein (a); Apo: apolipoprotein.