Research Article

Apolipoprotein E2 Genotype Is Associated with a 2-Fold Increase in the Incidence of Type 2 Diabetes Mellitus: Results from a Long-Term Observational Study

Table 2

Baseline characteristics of the 436 patients with different APOE alleles.

APOE2 carriersAPOE3 homozygotesAPOE4 carriersp value
(N=51)(N=283)(N=102)

Age – years53±1350±1444±15<0.001
Male – no. (%)32 (62.7)163 (57.6)60 (58.4)0.79
Weight – kg79±977±1476±140.51
SBP – mmHg135 (125-150)135 (122-146)126 (115-140)0.16
DBP – mmHg88 (80-90)80 (76-90)80 (70-90)0.09
TC – mmol.L−16.8 (5.7-8.5)7.0 (6.0-8.2)6.9 (5.9-7.9)0.53
HDL cholesterol – mmol.L−11.1 (1.0-1.4)1.2 (1.0-1.5)1.2 (0.9-1.5)0.46
LDL cholesterol – mmol.L−13.3 (2.6-4.5)4.1 (3.0-4.9)4.0 (3.0-5.3)0.04
Lp(a) – mmol.L−10.36 (0.13-0.93)0.39 (0.16-0.96)0.36 (0.16-0.96)0.94
ApoE – mmol.L−10.20 (0.15-0.33)0.14 (0.11-0.18)0.11 (0.09-0.16)<0.001
ApoB – mmol.L−13.1 (2.4-3.7)3.8 (3.1-4.5)3.5 (3.0-3.9)<0.001
ApoA – mmol.L−13.8 (3.2-4.4)4.0 (3.5-4.6)3.8 (3.2-4.4)0.28
ApoB/ApoA0.8 (0.6-1.0)1.0 (0.7-1.2)0.9 (.8-1.1)0.10
Triglycerides – mmol.L−18.7 (5.5-13.5)5.2 (3.2-8.8)4.5 (2.8-11.0)<0.001
Serum creatinine – µmol.L−168.6 (68.6 -76.3)68.6 (61.0-76.3)68.6 (61.0-76.3)0.65

APOE: apolipoprotein E; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; LDL: low-density lipoprotein; HDL: high-density lipoprotein; Lp(a): lipoprotein (a); Apo: apolipoprotein.