Journal of Lipids

Interactions between Bile Acids and Nuclear Receptors and Their Effects on Lipid Metabolism and Liver Diseases


Publishing date
15 Feb 2012
Status
Published
Submission deadline
15 Aug 2011

1Department of Medicine, Gastroenterology Division and Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA, USA

2Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, Saint Louis, MO, USA

3Department of Internal Medicine and Public Medicine, Clinica Medica “A. Murri”, University of Bari Medical School, Bari, Italy

4Department of Internal Medicine, Gastroenterology Division, McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA, USA


Interactions between Bile Acids and Nuclear Receptors and Their Effects on Lipid Metabolism and Liver Diseases

Description

Bile acids are made in the liver by the cytochrome P450-mediated oxidation of cholesterol and are found predominantly in the bile of mammals. Nuclear receptors are found within the interior of cells and are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. Also, they regulate gene transcription through interaction with cellular coactivators and corepressors. However, the interactions between bile acids and nuclear receptors on lipid metabolism and liver diseases have remained elusive.

We are pleased to invite investigators to contribute review articles and original research articles that will stimulate the continuing efforts to understand the molecular functions of nuclear receptors, the significance of bile acid-controlled signaling pathways, and their interactions in metabolic and hepatic diseases. We are particularly interested in articles providing new insights into the role of nuclear receptors in hepatic lipid metabolism, advances in the effects of bile acids on lipid metabolism and liver diseases through the nuclear receptor pathways, and current concepts in the treatment of nonalcoholic fatty liver disease and cholestasis. Potential topics include, but are not limited to:

  • Recent progress in the effect of bile acids on glucose metabolism and insulin resistance
  • Advances in the regulatory role of nuclear receptors in hepatic metabolism of lipids, bile acids, and lipoproteins
  • The role of bile acids as signaling molecules in the metabolic syndrome
  • The influence of nuclear receptors on bile flow and biliary lipid secretion
  • The molecular mechanisms of actions of nuclear receptors on cholelithiasis
  • New cellular and animal models to understand the molecular mechanisms of cholestasis
  • Pathophysiology of nonalcoholic fatty liver disease
  • Role of bile acids in inflammation
  • Recent developments in liver fibrosis research
  • Identification of new agonists and antagonists of nuclear receptors and their role in translational medicine

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jl/guidelines.html. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 560715
  • - Editorial

Interactions between Bile Acids and Nuclear Receptors and Their Effects on Lipid Metabolism and Liver Diseases

David Q.-H. Wang | Brent A. Neuschwander-Tetri | ... | William M. Pandak
  • Special Issue
  • - Volume 2012
  • - Article ID 304292
  • - Review Article

A Pleiotropic Role for the Orphan Nuclear Receptor Small Heterodimer Partner in Lipid Homeostasis and Metabolic Pathways

Gabriella Garruti | Helen H. Wang | ... | Piero Portincasa
  • Special Issue
  • - Volume 2012
  • - Article ID 934707
  • - Review Article

Nuclear Receptor Variants in Liver Disease

Roman Müllenbach | Susanne N. Weber | Frank Lammert
  • Special Issue
  • - Volume 2012
  • - Article ID 365798
  • - Review Article

Fatty Acid Oxidation and Cardiovascular Risk during Menopause: A Mitochondrial Connection?

Paulo J. Oliveira | Rui A. Carvalho | ... | Vilma A. Sardao
  • Special Issue
  • - Volume 2012
  • - Article ID 139875
  • - Review Article

Nuclear Receptors in Nonalcoholic Fatty Liver Disease

Jorge A. López-Velázquez | Luis D. Carrillo-Córdova | ... | Nahum Méndez-Sánchez
  • Special Issue
  • - Volume 2012
  • - Article ID 934396
  • - Review Article

Non-Alcoholic Fatty Liver Disease: The Bile Acid-Activated Farnesoid X Receptor as an Emerging Treatment Target

Michael Fuchs
  • Special Issue
  • - Volume 2012
  • - Article ID 302847
  • - Review Article

Ezetimibe: Its Novel Effects on the Prevention and the Treatment of Cholesterol Gallstones and Nonalcoholic Fatty Liver Disease

Ornella de Bari | Brent A. Neuschwander-Tetri | ... | David Q.-H. Wang
  • Special Issue
  • - Volume 2012
  • - Article ID 547643
  • - Review Article

Molecular Mechanisms Underlying the Link between Nuclear Receptor Function and Cholesterol Gallstone Formation

Mary Carmen Vázquez | Attilio Rigotti | Silvana Zanlungo
  • Special Issue
  • - Volume 2012
  • - Article ID 754067
  • - Review Article

Bile Acid Signaling in Liver Metabolism and Diseases

Tiangang Li | John Y. L. Chiang
Journal of Lipids
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