TY - JOUR A2 - Culea, Eugen AU - Barros, Natan Roberto de AU - Chagas, Paulo Augusto Marques AU - Borges, Felipe Azevedo AU - Gemeinder, Jose Lucio Padua AU - Miranda, Matheus Carlos Romeiro AU - Garms, Bruna Cambraia AU - Herculano, Rondinelli Donizetti PY - 2015 DA - 2015/11/08 TI - Diclofenac Potassium Transdermal Patches Using Natural Rubber Latex Biomembranes as Carrier SP - 807948 VL - 2015 AB - The aim of this study was to design a compound transdermal patch containing diclofenac potassium (Dic-K) using natural rubber latex (NRL) biomembrane. The NRL from Hevea brasiliensis is easily manipulated and low cost and presents high mechanical resistance. It is a biocompatible material which can stimulate natural angiogenesis and is capable of adhering cells on its surface. Recent researches have used the NRL for Transdermal Drug Delivery Systems (TDDSs). Dic-K is used for the treatment of rheumatoid arthritis and osteoarthritis and pain relief for postoperative and posttraumatic cases, as well as inflammation and edema. Results showed that the biomembrane can release Dic-K for up to 216 hours. The kinetics of the Dic-K release could be fitted with double exponential function. X-ray diffraction and Fourier Transform Infrared (FTIR) spectroscopy show some interaction by hydrogen bound. The results indicated the potential of the compound patch. SN - 2314-4866 UR - https://doi.org/10.1155/2015/807948 DO - 10.1155/2015/807948 JF - Journal of Materials PB - Hindawi Publishing Corporation KW - ER -