Additive Hazard Regression for the Analysis of Clustered Survival Data from Case-Cohort Studies

Table 2

Simulation results for the estimation of .

Design		Method
			Bias	SE	SEE	BSE	CP	Bias	SE	SEE	BSE	CP
A	0.5	SC	−0.0023	0.0730	0.0723	0.0748	0.945	−0.0018	0.0839	0.0823	0.0841	0.950
		WC	−0.0012	0.0739	0.0722	0.0717	0.940	0.0001	0.0841	0.0823	0.0791	0.943
		T	0.0002	0.0716	0.0723	0.0745	0.746	0.0013	0.0825	0.0820	0.0868	0.949
	2	SC	−0.0010	0.0725	0.0736	0.0664	0.947	−0.0022	0.0825	0.0831	0.0808	0.947
		WC	−0.0017	0.0732	0.0729	0.0683	0.932	0.0012	0.0837	0.0830	0.0709	0.937
		T	0.0021	0.0721	0.0730	0.0710	0.944	0.0031	0.0819	0.0827	0.0806	0.948
B	0.5	SC	−0.0013	0.0741	0.0714	0.0708	0.938	−0.0057	0.0857	0.0800	0.0684	0.924
		WC	−0.0002	0.0736	0.0716	0.0765	0.931	0.0053	0.0855	0.0799	0.0783	0.925
		T	0.0021	0.0734	0.0709	0.0619	0.927	−0.0030	0.0842	0.0806	0.0756	0.933
	2	SC	−0.0023	0.0738	0.0725	0.0625	0.938	−0.0042	0.0849	0.0813	0.0878	0.928
		WC	−0.0015	0.0724	0.0721	0.0697	0.934	0.0019	0.0858	0.0824	0.0774	0.930
		T	0.0032	0.0741	0.0714	0.0725	0.931	−0.0028	0.0836	0.0813	0.0833	0.940
C	0.5	SC	0.0005	0.0732	0.0715	0.0708	0.949	0.0007	0.0843	0.0811	0.0746	0.937
		WC	0.0002	0.0737	0.0718	0.0766	0.948	−0.0022	0.0814	0.0858	0.0878	0.937
		T	−0.0007	0.0707	0.0721	0.0744	0.948	−0.0035	0.0809	0.0813	0.0836	0.941
	2	SC	0.0014	0.0739	0.0723	0.0726	0.941	0.0014	0.0838	0.0820	0.0806	0.941
		WC	0.0010	0.0741	0.0730	0.0685	0.938	−0.0022	0.0823	0.0800	0.0763	0.935
		T	−0.0022	0.0712	0.0731	0.0709	0.948	−0.0015	0.0821	0.0817	0.0746	0.944

Estimate of from four methods: SC = estimating using the subcohort ; WC = estimating using the whole cohort, ; T = using true value, .