Table of Contents
Journal of Medical Engineering
Volume 2013 (2013), Article ID 808056, 7 pages
http://dx.doi.org/10.1155/2013/808056
Research Article

Detection of Myoglobin with an Open-Cavity-Based Label-Free Photonic Crystal Biosensor

University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA

Received 28 November 2012; Revised 28 April 2013; Accepted 28 April 2013

Academic Editor: Hala Zreiqat

Copyright © 2013 Bailin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The label-free detection of one of the cardiac biomarkers, myoglobin, using a photonic-crystal-based biosensor in a total-internal-reflection configuration (PC-TIR) is presented in this paper. The PC-TIR sensor possesses a unique open optical microcavity that allows for several key advantages in biomolecular assays. In contrast to a conventional closed microcavity, the open configuration allows easy functionalization of the sensing surface for rapid biomolecular binding assays. Moreover, the properties of PC structures make it easy to be designed and engineered for operating at any optical wavelength. Through fine design of the photonic crystal structure, biochemical modification of the sensor surface, and integration with a microfluidic system, we have demonstrated that the detection sensitivity of the sensor for myoglobin has reached the clinically significant concentration range, enabling potential usage of this biosensor for diagnosis of acute myocardial infarction. The real-time response of the sensor to the myoglobin binding may potentially provide point-of-care monitoring of patients and treatment effects.