Journal of Medical Engineering The latest articles from Hindawi Publishing Corporation © 2016 , Hindawi Publishing Corporation . All rights reserved. Comparison of the Lag Screw Placements for the Treatment of Stable and Unstable Intertrochanteric Femoral Fractures regarding Trabecular Bone Failure Tue, 22 Nov 2016 06:39:59 +0000 Background. In this study, the cut-out risk of Dynamic Hip Screw (DHS) was investigated in nine different positions of the lag screw for two fracture types by using Finite Element Analysis (FEA). Methods. Two types of fractures (31-A1.1 and A2.1 in AO classification) were generated in the femur model obtained from Computerized Tomography images. The DHS model was placed into the fractured femur model in nine different positions. Tip-Apex Distances were measured using SolidWorks. In FEA, the force applied to the femoral head was determined according to the maximum value being observed during walking. Results. The highest volume percentage exceeding the yield strength of trabecular bone was obtained in posterior-inferior region in both fracture types. The best placement region for the lag screw was found in the middle of both fracture types. There are compatible results between Tip-Apex Distances and the cut-out risk except for posterior-superior and superior region of 31-A2.1 fracture type. Conclusion. The position of the lag screw affects the risk of cut-out significantly. Also, Tip-Apex Distance is a good predictor of the cut-out risk. All in all, we can supposedly say that the density distribution of the trabecular bone is a more efficient factor compared to the positions of lag screw in the cut-out risk. Talip Celik, Ibrahim Mutlu, Arif Ozkan, and Yasin Kisioglu Copyright © 2016 Talip Celik et al. All rights reserved. A Hybrid Signal Processing of RR Intervals from QTc Variation Searching Arrhythmia and Improving Heart Rate Variability Assessment in Acute Large Artery Ischemic Stroke Mon, 14 Nov 2016 07:24:10 +0000 Sudden death caused by abnormal QTc and atrial fibrillation (AF) has been reported in stroke. Heart rate variability (HRV) is reduced with missing beats of RRI during arrhythmic episode and abnormal QTc variation during acute stroke. In this study, we develop a hybrid signal processing by Pan Tompkins QRS detection and Kalman filter estimator for meaningful missing beats and searching AF with prolonged QTc. We use this hybrid model to investigate RRIs of Lead II ECG in thirty acute stroke patients with long QTc and AF (LQTc-AF) and normal QTc without AF (NQTc-nonAF) and then assess them by HRV. In LQTc-AF Kalman, higher mean heart rate with lower mean RRIs compared to NQTc-nonAF Kalman was characterized. LQTc-AF Kalman showed significant increase in SDNN, HF, SD2, SD2/SD1, and sample entropy. SDNN and HF associated with high RMSSD, pNN50, and SD1 reflect predominant parasympathetic drive for sympathovagal balance in LQTc-AF Kalman. Greater SD2, SD2/SD1, and sample entropy indicate more scatter of Poincaré plot. Compared with conventional Labchart, fractal scaling exponent of α1 (DFA) is higher in LQTc-AF Kalman. Remarkable complexity with parasympathetic drive in LQTc-AF Kalman suggests an influence of missing beats during stroke. S. Rangsungnoen, P. Chanbenjapipu, N. Mathuradavong, and K. Suwanprasert Copyright © 2016 S. Rangsungnoen et al. All rights reserved. An Engineering Perspective of External Cardiac Loop Recorder: A Systematic Review Mon, 31 Oct 2016 11:45:43 +0000 External cardiac loop recorder (ELR) is a kind of ECG monitoring system that records cardiac activities of a subject continuously for a long time. When the heart palpitations are not the frequent and nonspecific character, it is difficult to diagnose the disease. In such a case, ELR is used for long-term monitoring of heart signal of the patient. But the cost of ELR is very high. Therefore, it is not prominently available in developing countries like India. Since the design of ELR includes the ECG electrodes, instrumentation amplifier, analog to digital converter, and signal processing unit, a comparative review of each part of the ELR is presented in this paper in order to design a cost effective, low power, and compact kind of ELR. This review will also give different choices available for selecting and designing each part of the ELR system. Finally, the review will suggest the better choice for designing a cost effective external cardiac loop recorder that helps to make it available even for rural people in India. Avvaru Srinivasulu and N. Sriraam Copyright © 2016 Avvaru Srinivasulu and N. Sriraam. All rights reserved. The Biomechanics and Optimization of the Needle-Syringe System for Injecting Triamcinolone Acetonide into Keloids Mon, 24 Oct 2016 14:04:25 +0000 Purpose. Injecting triamcinolone acetonide (TA) into a keloid is physically challenging due to the density of keloids. The purpose was to investigate the effects of various syringe and needle combinations on the injection force to determine the most ergonomic combination. Materials and Methods. A load cell was used to generate and measure the injection force. Phase 1: the injection force of 5 common syringes was measured by injecting water into air. The syringe that required the lowest injection force was evaluated with various needle gauges (25, 27, and 30 G) and lengths (16, 25, and 38 mm) by injecting TA (40 mg/mL) into air. The needle-syringe combination with the lowest injection force (CLIF) was deemed the most ergonomic combination. Phase 2: comparisons between the CLIF and a standard combination (SC) were performed by injecting TA into air and tap water into a keloid specimen. Intraclass Correlation Coefficient (ICC) and independent -test were used. Results. Increasing the syringe caliber, injection speed, and needle gauge and length significantly increased the injection force ( value < 0.001). The SC required a maximum force of 40.0 N to inject water into keloid, compared to 25.0 N for the CLIF. Injecting TA into keloid using the SC would require an injection force that was 103.5% of the maximum force female thumbs could exert compared to 64.8% for the CLIF. ICC values were greater than 0.4. Conclusions. The 1 mL polycarbonate syringe with a 25 G, 16 mm needle (CLIF) was the most ergonomic combination. The SC required a substantial injection force, which may represent a physical challenge for female thumbs. Anthony Vo, Marc Doumit, and Gloria Rockwell Copyright © 2016 Anthony Vo et al. All rights reserved. Assessment of Optimized Electrode Configuration for Electrical Impedance Myography Using Genetic Algorithm via Finite Element Model Mon, 24 Oct 2016 13:33:25 +0000 Electrical Impedance Myography (EIM) is a noninvasive neurophysiologic technique to diagnose muscle health. Besides muscle properties, the EIM measurements vary significantly with the change of some other anatomic and nonanatomic factors such as skin fat thickness, shape and thickness of muscle, and electrode size and spacing due to its noninvasive nature of measurement. In this study, genetic algorithm was applied along with finite element model of EIM as an optimization tool in order to figure out an optimized EIM electrode setup, which is less affected by these factors, specifically muscle thickness variation, but does not compromise EIM’s ability to detect muscle diseases. The results obtained suggest that a particular arrangement of electrodes and minimization of electrode surface area to its practical limit can overcome the effect of undesired factors on EIM parameters to a larger extent. Somen Baidya and Mohammad A. Ahad Copyright © 2016 Somen Baidya and Mohammad A. Ahad. All rights reserved. A Kinect-Based Physiotherapy and Assessment Platform for Parkinson’s Disease Patients Sun, 16 Oct 2016 09:50:39 +0000 We report on a Kinect-based, augmented reality, real-time physiotherapy platform tailored to Parkinson’s disease (PD) patients. The platform employs a Kinect sensor to extract real-time 3D skeletal data (joint information) from a patient facing the sensor (at 30 frames per second). In addition, a small collection of exercises practiced in traditional physiotherapy for PD patients has been implemented in the Unity 3D game engine. Each exercise employs linear or circular movement patterns and poses very light-weight processing demands on real-time computations. During an exercise, trainer instruction demonstrates correct execution and Kinect-provided 3D joint data are fed to the game engine and compared to exercise-specific control routines to assess proper posture and body control in real time. When an exercise is complete, performance metrics appropriate for that exercise are computed and displayed on screen to enable the attending physiotherapist to fine-tune the exercise to the abilities/needs of an individual patient as well as to provide performance feedback to the patient. The platform can operate in a physiotherapist’s office and, following appropriate validation, in a home environment. Finally, exercises can be parameterized meaningfully, depending on the intended purpose (motor assessment versus plain exercise at home). Ioannis Pachoulakis, Nikolaos Xilourgos, Nikolaos Papadopoulos, and Anastasia Analyti Copyright © 2016 Ioannis Pachoulakis et al. All rights reserved. Gradient Artefact Correction and Evaluation of the EEG Recorded Simultaneously with fMRI Data Using Optimised Moving-Average Tue, 28 Jun 2016 15:46:11 +0000 Over the past years, coregistered EEG-fMRI has emerged as a powerful tool for neurocognitive research and correlated studies, mainly because of the possibility of integrating the high temporal resolution of the EEG with the high spatial resolution of fMRI. However, additional work remains to be done in order to improve the quality of the EEG signal recorded simultaneously with fMRI data, in particular regarding the occurrence of the gradient artefact. We devised and presented in this paper a novel approach for gradient artefact correction based upon optimised moving-average filtering (OMA). OMA makes use of the iterative application of a moving-average filter, which allows estimation and cancellation of the gradient artefact by integration. Additionally, OMA is capable of performing the attenuation of the periodic artefact activity without accurate information about MRI triggers. By using our proposed approach, it is possible to achieve a better balance than the slice-average subtraction as performed by the established AAS method, regarding EEG signal preservation together with effective suppression of the gradient artefact. Since the stochastic nature of the EEG signal complicates the assessment of EEG preservation after application of the gradient artefact correction, we also propose a simple and effective method to account for it. José L. Ferreira, Yan Wu, René M. H. Besseling, Rolf Lamerichs, and Ronald M. Aarts Copyright © 2016 José L. Ferreira et al. All rights reserved. Possibilities of Preoperative Medical Models Made by 3D Printing or Additive Manufacturing Tue, 28 Jun 2016 11:46:19 +0000 Most of the 3D printing applications of preoperative models have been focused on dental and craniomaxillofacial area. The purpose of this paper is to demonstrate the possibilities in other application areas and give examples of the current possibilities. The approach was to communicate with the surgeons with different fields about their needs related preoperative models and try to produce preoperative models that satisfy those needs. Ten different kinds of examples of possibilities were selected to be shown in this paper and aspects related imaging, 3D model reconstruction, 3D modeling, and 3D printing were presented. Examples were heart, ankle, backbone, knee, and pelvis with different processes and materials. Software types required were Osirix, 3Data Expert, and Rhinoceros. Different 3D printing processes were binder jetting and material extrusion. This paper presents a wide range of possibilities related to 3D printing of preoperative models. Surgeons should be aware of the new possibilities and in most cases help from mechanical engineering side is needed. Mika Salmi Copyright © 2016 Mika Salmi. All rights reserved. Potential of M-Wave Elicited by Double Pulse for Muscle Fatigue Evaluation in Intermittent Muscle Activation by Functional Electrical Stimulation for Motor Rehabilitation Sun, 27 Mar 2016 11:12:51 +0000 Clinical studies on application of functional electrical stimulation (FES) to motor rehabilitation have been increasing. However, muscle fatigue appears early in the course of repetitive movement production training by FES. Although M-wave variables were suggested to be reliable indices of muscle fatigue in long lasting constant electrical stimulation under the isometric condition, the ability of M-wave needs more studies under intermittent stimulation condition, because the intervals between electrical stimulations help recovery of muscle activation level. In this paper, M-waves elicited by double pulses were examined in muscle fatigue evaluation during repetitive movements considering rehabilitation training with surface electrical stimulation. M-waves were measured under the two conditions of repetitive stimulation: knee extension force production under the isometric condition and the dynamic movement condition by knee joint angle control. Amplitude of M-wave elicited by the 2nd pulse of a double pulse decreased during muscle fatigue in both measurement conditions, while the change in M-waves elicited by single pulses in a stimulation burst was not relevant to muscle fatigue in repeated activation with stimulation interval of 1 s. Fatigue index obtained from M-waves elicited by 2nd pulses was suggested to provide good estimation of muscle fatigue during repetitive movements with FES. Naoto Miura and Takashi Watanabe Copyright © 2016 Naoto Miura and Takashi Watanabe. All rights reserved. Labview Based ECG Patient Monitoring System for Cardiovascular Patient Using SMTP Technology Thu, 10 Dec 2015 11:34:49 +0000 This paper leads to developing a Labview based ECG patient monitoring system for cardiovascular patient using Simple Mail Transfer Protocol technology. The designed device has been divided into three parts. First part is ECG amplifier circuit, built using instrumentation amplifier (AD620) followed by signal conditioning circuit with the operation amplifier (lm741). Secondly, the DAQ card is used to convert the analog signal into digital form for the further process. Furthermore, the data has been processed in Labview where the digital filter techniques have been implemented to remove the noise from the acquired signal. After processing, the algorithm was developed to calculate the heart rate and to analyze the arrhythmia condition. Finally, SMTP technology has been added in our work to make device more communicative and much more cost-effective solution in telemedicine technology which has been key-problem to realize the telediagnosis and monitoring of ECG signals. The technology also can be easily implemented over already existing Internet. Om Prakash Singh, Dawit Mekonnen, and M. B. Malarvili Copyright © 2015 Om Prakash Singh et al. All rights reserved. An Irregularity Measurement Based Cardiac Status Recognition Using Support Vector Machine Tue, 27 Oct 2015 07:49:06 +0000 An automated robust feature extraction technique is proposed in this paper based on inherent structural distribution of heart sound to analyze the phonocardiogram signal in presence of environmental noise and interference of lung sound signal. The structural complexity of the heart sound signal is estimated in terms of sample entropy using a nonlinear signal processing framework. The effectiveness of the feature is evaluated using a support vector machine under two different circumstances which include Gaussian noise and pulmonary perturbation. The analysis framework has been executed on a composite data set of 60 healthy and 60 pathological individuals for different SNR levels (−5 to 10 dB) and the performance accuracy is close to that of the clean signal. In addition, a comparative study has been done with conventional approaches which includes waveform analysis, spectral domain inspection, and spectrogram evaluation. The experimental results show that sample entropy based classification method gives an accuracy of 96.67% for clean data and 91.66% for noisy data of SNR 10 dB. The result suggests that the proposed method performs significantly well over the visual and audio test. Poulami Banerjee and Ashok Mondal Copyright © 2015 Poulami Banerjee and Ashok Mondal. All rights reserved. Detection and Classification of Cancer from Microscopic Biopsy Images Using Clinically Significant and Biologically Interpretable Features Sun, 23 Aug 2015 09:17:46 +0000 A framework for automated detection and classification of cancer from microscopic biopsy images using clinically significant and biologically interpretable features is proposed and examined. The various stages involved in the proposed methodology include enhancement of microscopic images, segmentation of background cells, features extraction, and finally the classification. An appropriate and efficient method is employed in each of the design steps of the proposed framework after making a comparative analysis of commonly used method in each category. For highlighting the details of the tissue and structures, the contrast limited adaptive histogram equalization approach is used. For the segmentation of background cells, -means segmentation algorithm is used because it performs better in comparison to other commonly used segmentation methods. In feature extraction phase, it is proposed to extract various biologically interpretable and clinically significant shapes as well as morphology based features from the segmented images. These include gray level texture features, color based features, color gray level texture features, Law’s Texture Energy based features, Tamura’s features, and wavelet features. Finally, the -nearest neighborhood method is used for classification of images into normal and cancerous categories because it is performing better in comparison to other commonly used methods for this application. The performance of the proposed framework is evaluated using well-known parameters for four fundamental tissues (connective, epithelial, muscular, and nervous) of randomly selected 1000 microscopic biopsy images. Rajesh Kumar, Rajeev Srivastava, and Subodh Srivastava Copyright © 2015 Rajesh Kumar et al. All rights reserved. Identification of Premature Ventricular Cycles of Electrocardiogram Using Discrete Cosine Transform-Teager Energy Operator Model Mon, 02 Mar 2015 11:18:00 +0000 An algorithm based on the ability of TEO to track the changes in the envelope of ECG signal is proposed for identifying PVCs in ECG. Teager energy is calculated from DCT coefficients of ECG signal. This method can be considered as computationally efficient algorithm when compared with the well-known DCT cepstrum technique. EPE is derived from the teager energy of DCT coefficients in DCT-TEO method and from the cepstrum of DCT coefficients in the existing method. EPE determines the decay rate of the action potential of ECG beat and provides sufficient information to identify the PVC beats in ECG data. EPEs obtained by DCT-TEO and existing DCT cepstrum models are compared. The proposed algorithm has resulted in performance measures like sensitivity of 98–100%, positive predictivity of 100%, and detection error rate of 0.03%, when tested on MIT-BIH database signals consisting of PVC and normal beats. Result analysis reveals that the DCT-TEO algorithm worked well in clear identification of PVCs from normal beats compared to the existing algorithm, even in the presence of artifacts like baseline wander, PLI, and noise with SNR of up to −5 dB. Vallem Sharmila and K. Ashoka Reddy Copyright © 2015 Vallem Sharmila and K. Ashoka Reddy. All rights reserved. Electrical Bioimpedance Analysis: A New Method in Cervical Cancer Screening Mon, 02 Feb 2015 13:00:03 +0000 Cervical cancer is the second most common female cancer worldwide and a disease of concern due to its high rate of incidence of about 500,000 women annually and is responsible for about 280,000 deaths in a year. The mortality and morbidity of cervical cancer are reduced through mass screening via Pap smear, but this technique suffers from very high false negativity of around 30% to 40% and hence the sensitivity of this technique is not more than 60%. Electrical bioimpedance study employing cytosensors over a frequency range offers instantaneous and quantitative means to monitor cellular events and is an upcoming technique in real time to classify cells as normal and abnormal ones. This technology is exploited for label-free detection of diseases by identifying and measuring nonbiological parameters of the cell which may carry the disease signature. Lopamudra Das, Soumen Das, and Jyotirmoy Chatterjee Copyright © 2015 Lopamudra Das et al. All rights reserved. Kaczmarz Iterative Projection and Nonuniform Sampling with Complexity Estimates Mon, 15 Dec 2014 00:10:01 +0000 Kaczmarz’s alternating projection method has been widely used for solving mostly over-determined linear system of equations in various fields of engineering, medical imaging, and computational science. Because of its simple iterative nature with light computation, this method was successfully applied in computerized tomography. Since tomography generates a matrix with highly coherent rows, randomized Kaczmarz algorithm is expected to provide faster convergence as it picks a row for each iteration at random, based on a certain probability distribution. Since Kaczmarz’s method is a subspace projection method, the convergence rate for simple Kaczmarz algorithm was developed in terms of subspace angles. This paper provides analyses of simple and randomized Kaczmarz algorithms and explains the link between them. New versions of randomization are proposed that may speed up convergence in the presence of nonuniform sampling, which is common in tomography applications. It is anticipated that proper understanding of sampling and coherence with respect to convergence and noise can improve future systems to reduce the cumulative radiation exposures to the patient. Quantitative simulations of convergence rates and relative algorithm benchmarks have been produced to illustrate the effects of measurement coherency and algorithm performance, respectively, under various conditions in a real-time kernel. Tim Wallace and Ali Sekmen Copyright © 2014 Tim Wallace and Ali Sekmen. All rights reserved. A Review on Technical and Clinical Impact of Microsoft Kinect on Physical Therapy and Rehabilitation Thu, 11 Dec 2014 00:10:08 +0000 This paper reviews technical and clinical impact of the Microsoft Kinect in physical therapy and rehabilitation. It covers the studies on patients with neurological disorders including stroke, Parkinson’s, cerebral palsy, and MS as well as the elderly patients. Search results in Pubmed and Google scholar reveal increasing interest in using Kinect in medical application. Relevant papers are reviewed and divided into three groups: (1) papers which evaluated Kinect’s accuracy and reliability, (2) papers which used Kinect for a rehabilitation system and provided clinical evaluation involving patients, and (3) papers which proposed a Kinect-based system for rehabilitation but fell short of providing clinical validation. At last, to serve as technical comparison to help future rehabilitation design other sensors similar to Kinect are reviewed. Hossein Mousavi Hondori and Maryam Khademi Copyright © 2014 Hossein Mousavi Hondori and Maryam Khademi. All rights reserved. A Structured Approach for Investigating the Causes of Medical Device Adverse Events Thu, 27 Nov 2014 10:22:09 +0000 Aim. Medical device-related adverse events are often ascribed to “device” or “operator” failure although there are more complex causes. A structured approach, viewing the device in its clinical context, is developed to assist in-depth investigations of the causes. Method. Medical device applications involve devices, clinical teams, patients, and supporting infrastructure. The literature was explored for investigations and approaches to investigations, particularly structured approaches. From this a conceptual framework of causes was developed based primarily on device and clinical team caring for the patient within a supporting infrastructure, each aspect having detailed subdivisions. The approach was applied to incidents from the literature and an anonymous incident database. Results. The approach identified and classified the underlying causes of incidents described in the literature, exploring the details of “device,” “operator,” or “infrastructure” failures. Applied to incident databases it suggested that causes differ between device types and identified the causes of device unavailability. Discussion. The structured approach enables digging deeper to uncover the wider causes rather than ascribing to device or user fault. It can assess global patterns of causes. It can help develop consistent terminology for describing and sharing information on the causes of medical device adverse events. John N. Amoore Copyright © 2014 John N. Amoore. All rights reserved. Material Properties of the Mandibular Trabecular Bone Wed, 29 Oct 2014 11:09:38 +0000 The present paper introduces a numerical simulation aided, experimental method for the measurement of Young’s modulus of the trabecular substance in the human mandible. Compression tests were performed on fresh cadaveric samples containing trabecular bone covered with cortical layer, thus avoiding the destruction caused by the sterilization, preservation, and storage and the underestimation of the stiffness resulting from the individual failure of the trabeculae cut on the surfaces. The elastic modulus of the spongiosa was determined by the numerical simulation of each compression test using a specimen specific finite element model of each sample. The received mandibular trabecular bone Young’s modulus values ranged from 6.9 to 199.5 MPa. Éva Lakatos, Lóránt Magyar, and Imre Bojtár Copyright © 2014 Éva Lakatos et al. All rights reserved. Image Segmentation and Analysis of Flexion-Extension Radiographs of Cervical Spines Mon, 13 Oct 2014 12:14:20 +0000 We present a new analysis tool for cervical flexion-extension radiographs based on machine vision and computerized image processing. The method is based on semiautomatic image segmentation leading to detection of common landmarks such as the spinolaminar (SL) line or contour lines of the implanted anterior cervical plates. The technique allows for visualization of the local curvature of these landmarks during flexion-extension experiments. In addition to changes in the curvature of the SL line, it has been found that the cervical plates also deform during flexion-extension examination. While extension radiographs reveal larger curvature changes in the SL line, flexion radiographs on the other hand tend to generate larger curvature changes in the implanted cervical plates. Furthermore, while some lordosis is always present in the cervical plates by design, it actually decreases during extension and increases during flexion. Possible causes of this unexpected finding are also discussed. The described analysis may lead to a more precise interpretation of flexion-extension radiographs, allowing diagnosis of spinal instability and/or pseudoarthrosis in already seemingly fused spines. Eniko T. Enikov and Rein Anton Copyright © 2014 Eniko T. Enikov and Rein Anton. All rights reserved. Automated Cough Assessment on a Mobile Platform Sun, 10 Aug 2014 12:56:26 +0000 The development of an Automated System for Asthma Monitoring (ADAM) is described. This consists of a consumer electronics mobile platform running a custom application. The application acquires an audio signal from an external user-worn microphone connected to the device analog-to-digital converter (microphone input). This signal is processed to determine the presence or absence of cough sounds. Symptom tallies and raw audio waveforms are recorded and made easily accessible for later review by a healthcare provider. The symptom detection algorithm is based upon standard speech recognition and machine learning paradigms and consists of an audio feature extraction step followed by a Hidden Markov Model based Viterbi decoder that has been trained on a large database of audio examples from a variety of subjects. Multiple Hidden Markov Model topologies and orders are studied. Performance of the recognizer is presented in terms of the sensitivity and the rate of false alarm as determined in a cross-validation test. Mark Sterling, Hyekyun Rhee, and Mark Bocko Copyright © 2014 Mark Sterling et al. All rights reserved. Bioelectrical Impedance Methods for Noninvasive Health Monitoring: A Review Tue, 17 Jun 2014 12:53:02 +0000 Under the alternating electrical excitation, biological tissues produce a complex electrical impedance which depends on tissue composition, structures, health status, and applied signal frequency, and hence the bioelectrical impedance methods can be utilized for noninvasive tissue characterization. As the impedance responses of these tissue parameters vary with frequencies of the applied signal, the impedance analysis conducted over a wide frequency band provides more information about the tissue interiors which help us to better understand the biological tissues anatomy, physiology, and pathology. Over past few decades, a number of impedance based noninvasive tissue characterization techniques such as bioelectrical impedance analysis (BIA), electrical impedance spectroscopy (EIS), electrical impedance plethysmography (IPG), impedance cardiography (ICG), and electrical impedance tomography (EIT) have been proposed and a lot of research works have been conducted on these methods for noninvasive tissue characterization and disease diagnosis. In this paper BIA, EIS, IPG, ICG, and EIT techniques and their applications in different fields have been reviewed and technical perspective of these impedance methods has been presented. The working principles, applications, merits, and demerits of these methods has been discussed in detail along with their other technical issues followed by present status and future trends. Tushar Kanti Bera Copyright © 2014 Tushar Kanti Bera. All rights reserved. Quantitative Analysis of Diffusion Weighted MR Images of Brain Tumor Using Signal Intensity Gradient Technique Wed, 28 May 2014 13:18:13 +0000 The purpose of this study was to evaluate the role of diffusion weighted-magnetic resonance imaging (DW-MRI) in the examination and classification of brain tumors, namely, glioma and meningioma. Our hypothesis was that as signal intensity variations on diffusion weighted (DW) images depend on histology and cellularity of the tumor, analysing the signal intensity characteristics on DW images may allow differentiating between the tumor types. Towards this end the signal intensity variations on DW images of the entire tumor volume data of 20 subjects with glioma and 12 subjects with meningioma were investigated and quantified using signal intensity gradient (SIG) parameter. The relative increase in the SIG values (RSIG) for the subjects with glioma and meningioma was in the range of 10.08–28.36 times and 5.60–9.86 times, respectively, compared to their corresponding SIG values on the contralateral hemisphere. The RSIG values were significantly different between the subjects with glioma and meningioma , with no overlap between RSIG values across the two tumors. The results indicate that the quantitative changes in the RSIG values could be applied in the differential diagnosis of glioma and meningioma, and their adoption in clinical diagnosis and treatment could be helpful and informative. S. S. Shanbhag, G. R. Udupi, K. M. Patil, and K. Ranganath Copyright © 2014 S. S. Shanbhag et al. All rights reserved. A Simple and Inexpensive Stereotactic Guidance Frame for MRI-Guided Brain Biopsy in Canines Sun, 18 May 2014 12:44:20 +0000 A magnetic resonance imaging (MRI) guided stereotactic system was developed to provide veterinarians a method to accomplish minimally invasive stereotactic brain biopsies and procedures involving the cerebrum in canines. While MR-guided procedures are prevalent for humans, they are less common in animal practices. The system was designed to minimize fabrication costs in an effort to make such procedures more accessible in the veterinary field. A frame constrained the head without the need for punctures and supported registration and guidance attachments. Location data for registration and relevant structures were selected by the clinician, and a reverse kinematic analysis program generated the settings of the stereotactic arch to guide a needle to the desired location. Phantom experiments and three cadaver trials showed an average targeting error of <3 mm using the system. Alexander D. Squires, Yabiao Gao, Sean F. Taylor, Marc Kent, and Zion Tsz Ho Tse Copyright © 2014 Alexander D. Squires et al. All rights reserved. A Digital Model to Simulate Effects of Bone Architecture Variations on Texture at Spatial Resolutions of CT, HR-pQCT, and μCT Scanners Sun, 18 May 2014 09:09:06 +0000 The quantification of changes in the trabecular bone structure induced by musculoskeletal diseases like osteoarthritis, osteoporosis, rheumatoid arthritis, and others by means of a texture analysis is a valuable tool which is expected to improve the diagnosis and monitoring of a disease. The reaction of texture parameters on different alterations in the architecture of the fine trabecular network and inherent imaging factors such as spatial resolution or image noise has to be understood in detail to ensure an accurate and reliable determination of the current bone state. Therefore, a digital model for the quantitative analysis of cancellous bone structures was developed. Five parameters were used for texture analysis: entropy, global and local inhomogeneity, local anisotropy, and variogram slope. Various generic structural changes of cancellous bone were simulated for different spatial resolutions. Additionally, the dependence of the texture parameters on tissue mineralization and noise was investigated. The present work explains changes in texture parameter outcomes based on structural changes originating from structure modifications and reveals that a texture analysis could provide useful information for a trabecular bone analysis even at resolutions below the dimensions of single trabeculae. T. Lowitz, O. Museyko, V. Bousson, W. A. Kalender, J.-D. Laredo, and K. Engelke Copyright © 2014 T. Lowitz et al. All rights reserved. Assessment of Visual Reliance in Balance Control: An Inexpensive Extension of the Static Posturography Wed, 19 Feb 2014 11:56:16 +0000 Ability of humans to maintain balance in an upright stance and during movement activities is one of the most natural skills affecting everyday life. This ability progressively deteriorates with increasing age, and balance impairment, often aggravated by age-related diseases, can result in falls that adversely impact the quality of life. Falls represent serious problems of health concern associated with aging. Many investigators, involved in different science disciplines such as medicine, engineering, psychology, and sport, have been attracted by a research of the human upright stance. In a clinical practice, stabilometry based on the force plate is the most widely available procedure used to evaluate the balance. In this paper, we have proposed a low-cost extension of the conventional stabilometry by the multimedia technology that allows identifying potentially disturbing effects of visual sensory information. Due to the proposed extension, a stabilometric assessment in terms of line integral of center of pressure (COP) during moving scene stimuli shows higher discrimination power between young healthy and elderly subjects with supposed stronger visual reliance. Jozef Púčik, Marián Šaling, Tomáš Lukáč, Oldřich Ondráček, and Martin Kucharík Copyright © 2014 Jozef Púčik et al. All rights reserved. Detect AD Patients by Using EEG Coherence Analysis Mon, 10 Feb 2014 11:24:43 +0000 The purpose of this study is to discriminate mild Alzheimer’s disease (AD) patients from the normal aging. The EEG coherence was applied to analyze the data from auditory oddball paradigm to discriminate the differences of corticocortical connections between mild AD patients and healthy subjects. The results showed that the lower values of coherence were performed in mild AD patients than in the normal aging subjects, especially in theta band. The implications and suggestions are shown in this study. Ming-Chung Ho, Tsung-Ching Chen, Chin-Fei Huang, Cheng-Hsieh Yu, Jhih-Ming Chen, Ray-Ying Huang, Hsing-Chung Ho, and Chia-Ju Liu Copyright © 2014 Ming-Chung Ho et al. All rights reserved. Empirical Evaluation of Visual Fatigue from Display Alignment Errors Using Cerebral Hemodynamic Responses Tue, 24 Dec 2013 09:21:11 +0000 The purpose of this study was to investigate the effect of stereoscopic display alignment errors on visual fatigue and prefrontal cortical tissue hemodynamic responses. We collected hemodynamic data and perceptual ratings of visual fatigue while participants performed visual display tasks on 8 ft 6 ft NEC LT silver screen with NEC LT 245 DLP projectors. There was statistical significant difference between subjective measures of visual fatigue before air traffic control task (BATC) and after air traffic control task (ATC 3), (). Statistical significance was observed between left dorsolateral prefrontal cortex oxygenated hemoglobin (l DLPFC-HbO2), left dorsolateral prefrontal cortex deoxygenated hemoglobin (l DLPFC-Hbb), and right dorsolateral prefrontal cortex deoxygenated hemoglobin (r DLPFC-Hbb) on stereoscopic alignment errors (). Thus, cortical tissue oxygenation requirement in the left hemisphere indicates that the effect of visual fatigue is more pronounced in the left dorsolateral prefrontal cortex. Hanniebey D. Wiyor and Celestine A. Ntuen Copyright © 2013 Hanniebey D. Wiyor and Celestine A. Ntuen. All rights reserved. Extraction of Blood Vessels in Retinal Images Using Four Different Techniques Tue, 17 Dec 2013 10:33:39 +0000 A variety of blood vessel extraction (BVE) techniques exist in the literature, but they do not always lead to acceptable solutions especially in the presence of anomalies where the reported work is limited. Four techniques are presented for BVE: (1) BVE using Image Line Cross-Sections (ILCS), (2) BVE using Edge Enhancement and Edge Detection (EEED), (3) BVE using Modified Matched Filtering (MMF), and (4) BVE using Continuation Algorithm (CA). These four techniques have been designed especially for abnormal retinal images containing low vessel contrasts, drusen, exudates, and other artifacts. The four techniques were applied to 30 abnormal retinal images, and the success rate was found to be (95 to 99%) for CA, (88–91%) for EEED, (80–85%) for MMF, and (74–78%) for ILCS. Application of these four techniques to 105 normal retinal images gave improved results: (99-100%) for CA, (96–98%) for EEED, (94-95%) for MMF, and (88–93%) for ILCS. Investigations revealed that the four techniques in the order of increasing performance could be arranged as ILCS, MMF, EEED, and CA. Here we demonstrate these four techniques for abnormal retinal images only. ILCS, EEED, and CA are novel additions whereas MMF is an improved and modified version of an existing matched filtering technique. CA is a promising technique. Asloob Ahmad Mudassar and Saira Butt Copyright © 2013 Asloob Ahmad Mudassar and Saira Butt. All rights reserved. Applying the Bispectral Analysis on Widespread Diffuse Cross-Frequency Interactive Effects Tue, 10 Dec 2013 13:34:14 +0000 The aim of this paper is applying the bispectral analysis on widespread diffuse cross-frequency interactive effects. The event-related potentials (ERPs) research method was used in this study and it could collect the widespread diffuse cross-frequency from mild cognitive impairment (MCI) patients’ brain wave. In this study, the brain wave data were collected from 12 MCI subjects, 12 healthy elderly, and 12 healthy young. The findings showed that the decreased interhemispheric coherence of 8.8 Hz for MCI compared with healthy elderly in the central-parietal cortex to respective surrounding sites and each MCI subject showed significantly widespread diffuse pattern of cross-frequency interactions in comparison with the healthy controls in the left central-parietal and right frontal. This study provides some explanation and suggestions for these findings. Chia-Ju Liu, Cheng-Hsieh Yu, Chin-Fei Huang, Ray-Ying Huang, Chung-Jung Wang, Yi-Shan Liu, Tsung-Ching Chen, and Ming-Chung Ho Copyright © 2013 Chia-Ju Liu et al. All rights reserved. Markerless Lung Tumor Motion Tracking by Dynamic Decomposition of X-Ray Image Intensity Sun, 08 Dec 2013 09:56:06 +0000 We propose a new markerless tracking technique of lung tumor motion by using an X-ray fluoroscopic image sequence for real-time image-guided radiation therapy (IGRT). A core innovation of the new technique is to extract a moving tumor intensity component from the fluoroscopic image intensity. The fluoroscopic intensity is the superimposition of intensity components of all the structures passed through by the X-ray. The tumor can then be extracted by decomposing the fluoroscopic intensity into the tumor intensity component and the others. The decomposition problem for more than two structures is ill posed, but it can be transformed into a well-posed one by temporally accumulating constraints that must be satisfied by the decomposed moving tumor component and the rest of the intensity components. The extracted tumor image can then be used to achieve accurate tumor motion tracking without implanted markers that are widely used in the current tracking techniques. The performance evaluation showed that the extraction error was sufficiently small and the extracted tumor tracking achieved a high and sufficient accuracy less than 1 mm for clinical datasets. These results clearly demonstrate the usefulness of the proposed method for markerless tumor motion tracking. Noriyasu Homma, Yoshihiro Takai, Haruna Endo, Kei Ichiji, Yuichiro Narita, Xiaoyong Zhang, Masao Sakai, Makoto Osanai, Makoto Abe, Norihiro Sugita, and Makoto Yoshizawa Copyright © 2013 Noriyasu Homma et al. All rights reserved.