Recurring Events of Candida krusei Septicaemia: First Report from an ICU

Table 1

Differential characteristics in three successive outbreaks.

Characteristic features	Outbreak 1	Outbreak 2 [5]	Outbreak 3
Causative agent	Candida nonalbicans	Candida krusei	Candida krusei
Duration of outbreak	2 days	11 days	10 days
Number of affected neonates	2	7	4
Gestational age at delivery	28 weeks (1); 30 weeks (1)	28 weeks (5); 30 weeks (1); 36 weeks (1)	26 weeks (1); 28 weeks (1); 37 weeks (2)
Host factors	Prematurity, low birth weight, asphyxia, and TPN	Prematurity, asphyxia, low birth weight, IUGR, and TPN	VLBW, TPN, Apnea of prematurity, HIE III, and meconium stained liquor
Susceptible antifungals	Not tested, but patients responded after treatment with amphotericin B	Amphotericin B, caspofungin, micafungin, anidulafungin	Amphotericin B, caspofungin, micafungin, and posaconazole
Resistant antifungals	Not tested	Fluconazole	Fluconazole, flucytosine
Outcome	No attributable mortality	No attributable mortality	One recovered, three expired

HIE: Hypoxic Ischemic Encephalopathy, VLBW: very low birth weight, IUGR: Intrauterine Growth Retardation, and TPN: Total Parenteral Nutrition.