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Journal of Nucleic Acids
Volume 2010, Article ID 147528, 6 pages
http://dx.doi.org/10.4061/2010/147528
Research Article

Expression Levels of Some Antioxidant and Epidermal Growth Factor Receptor Genes in Patients with Early-Stage Non-Small Cell Lung Cancer

1Department of Experimental and Applied Medicine, Section of Occupational Health and Industrial Hygiene, University of Brescia, Piazzale Spedali Civili, 1, 25123 Brescia, Italy
2ISPESL Research Center at the University of Parma, via Gramsci 14, 43100 Parma, Italy
3Laboratory of Industrial Toxicology, Department of Clinical Medicine Nephrology and Health Sciences, University of Parma, via Gramsci 14, 43100 Parma, Italy
4Thoracic Surgery Unit, University of Parma, via Gramsci 14, 43100 Parma, Italy
5Division of Medical Oncology, University of Parma, via Gramsci 14, 43100 Parma, Italy

Received 24 November 2009; Revised 21 January 2010; Accepted 27 January 2010

Academic Editor: Hiroshi Sugiyama

Copyright © 2010 Giuseppe De Palma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, R. Siegel, E. Ward et al., “Cancer statistics,” CA: Cancer Journal for Clinicians, vol. 58, no. 2, pp. 71–96, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. D. G. Beer, S. L. Kardia, C. C. Huang et al., “Gene-expression profiles predict survival of patients with lung adenocarcinoma,” Nature Medicine, vol. 8, no. 8, pp. 816–824, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Y. Chen, S. L. Yu, C. H. Chen et al., “A five-gene signature and clinical outcome in non-small-cell lung cancer,” The New England Journal of Medicine, vol. 356, no. 1, pp. 11–20, 2007. View at Google Scholar · View at Scopus
  4. A. Potti, S. Mukherjee, R. Petersen et al., “A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer,” The New England Journal of Medicine, vol. 355, no. 6, pp. 570–580, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. J. E. Klaunig and L. M. Kamendulis, “The role of oxidative stress in carcinogenesis,” Annual Review of Pharmacology and Toxicology, vol. 44, pp. 239–267, 2004. View at Google Scholar
  6. R. Franco, O. Schoneveld, A. G. Georgakilas, and M. I. Panayiotidis, “Oxidative stress, DNA methylation and carcinogenesis,” Cancer Letters, vol. 266, no. 1, pp. 6–11, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Valko, C. J. Rhodes, J. Moncol, M. Izakovic, and M. Mazur, “Free radicals, metals and antioxidants in oxidative stress-induced cancer,” Chemico-Biological Interactions, vol. 160, no. 1, pp. 1–40, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Behrend, G. Henderson, and R. M. Zwacka, “Reactive oxygen species in oncogenic transformation,” Biochemical Society Transactions, vol. 31, no. 6, pp. 1441–1444, 2003. View at Google Scholar · View at Scopus
  9. L. E. Otterbein and A. M. K. Choi, “Heme oxygenase: colors of defense against cellular stress,” American Journal of Physiology, vol. 279, no. 6, pp. L1029–L1037, 2000. View at Google Scholar
  10. L. E. Fredenburgh, M. A. Perrella, and S. A. Mitsialis, “The role of heme oxygenase-1 in pulmonary disease,” American Journal of Respiratory Cell and Molecular Biology, vol. 36, no. 2, pp. 158–165, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. I. Fridovich, “Superoxide radical and superoxide dismutases,” Annual Review of Biochemistry, vol. 64, pp. 97–112, 1995. View at Google Scholar
  12. E. Giannoni, F. Buricchi, G. Grimaldi et al., “Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival,” Cell Death and Differentiation, vol. 15, no. 5, pp. 867–878, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. H. L. Chan, H. C. Chou, M. Duran et al., “Major role of EGFR and SRC kinases in promoting oxidative stress-dependent loss of adhesion and apoptosis in epithelial cells,” The Journal of Biological Chemistry, vol. 285, no. 7, pp. 4307–4318, 2010. View at Google Scholar
  14. K. Nakai, K. Yoneda, J. Igarashi, T. Moriue, H. Kosaka, and Y. Kubota, “Angiotensin II enhances EGF receptor expression levels via ROS formation in HaCaT cells,” Journal of Dermatological Science, vol. 51, no. 3, pp. 181–189, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S. V. Sharma and J. Settleman, “ErbBs in lung cancer,” Experimental Cell Research, vol. 315, no. 4, pp. 557–571, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. S. R. Hubbard and W. T. Miller, “Receptor tyrosine kinases: mechanisms of activation and signaling,” Current Opinion in Cell Biology, vol. 19, no. 2, pp. 117–123, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Yarden and M. X. Sliwkowski, “Untangling the ErbB signaling network,” Nature Reviews Molecular Cell Biology, vol. 2, no. 2, pp. 127–137, 2001. View at Google Scholar
  18. J. Vandesompele, K. De Preter, F. Pattyn et al., “Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes,” Genome Biology, vol. 3, no. 7, Article ID RESEARCH0034, 2002. View at Google Scholar · View at Scopus
  19. C. F. Mountain, “Revisions in the international system for staging lung cancer,” Chest, vol. 111, no. 6, pp. 1710–1717, 1997. View at Google Scholar · View at Scopus
  20. V. L. Kinnula and J. D. Crapo, “Superoxide dismutases in malignant cells and human tumours,” Free Radical Biology and Medicine, vol. 36, no. 6, pp. 718–744, 2004. View at Google Scholar
  21. J. Chung-man Ho, S. Zheng, S. A. Comhair, C. Farver, and S. C. Erzurum, “Differential expression of manganese superoxide dismutase and catalase in lung cancer,” Cancer Research, vol. 61, no. 23, pp. 8578–8585, 2001. View at Google Scholar · View at Scopus
  22. A. Jozkowicz, H. Was, and J. Dulak, “Heme oxygenase-1 in tumors: is it a false friend?” Antioxidants ' Redox Signaling, vol. 9, no. 12, pp. 2099–2117, 2007. View at Google Scholar
  23. P. Boschetto, E. Zeni, L. Mazzetti et al., “Decreased heme-oxygenase (HO)-1 in the macrophages of non-small cell lung cancer,” Lung Cancer, vol. 59, no. 2, pp. 192–197, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. A. -P. Meert, B. Martin, M. Paesmans et al., “The role of HER-2/neu expression on the survival of patients with lung cancer: a systematic review of the literature,” British Journal of Cancer, vol. 89, no. 6, pp. 959–965, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Onn, A. M. Correa, M. Gilcrease et al., “Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage i non-small cell lung cancer,” Clinical Cancer Research, vol. 10, no. 1 I, pp. 136–143, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. F. R. Hirsch, G. V. Scagliotti, C. J. Langer, M. Varella-Garcia, and W. A. Franklin, “Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies,” Lung Cancer, vol. 41, supplement 1, pp. S29–S42, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. P. S. Sharma, R. Sharma, and T. Tyagi, “Receptor tryosine kinase inhibitors as potent weapons in war against cancers,” Current Pharmaceutical Design, vol. 15, no. 7, pp. 758–776, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Pfannschmidt, T. Muley, H. Bulzebruck, H. Hoffmann, and H. Dienemann, “Prognostic assessment after surgical resection for non-small cell lung cancer: experiences in 2083 patients,” Lung Cancer, vol. 55, no. 3, pp. 371–377, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Baselga, J. Albanell, M. A. Molina, and J. Arribas, “Mechanism of action of trastuzumab and scientific update,” Seminars in Oncology, vol. 28, no. 5, supplement 16, pp. 4–11, 2001. View at Google Scholar · View at Scopus
  30. J. Schlessinger, “Common and distinct elements in cellular signaling via EGF and FGF receptor,” Science, vol. 306, no. 5701, pp. 1506–1507, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. X. F. Wen, G. Yang, W. Mao et al., “HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy,” Oncogene, vol. 25, no. 52, pp. 6986–6996, 2006. View at Publisher · View at Google Scholar · View at Scopus