Research ArticleDesign, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide--Deoxyguanosine Hybrids
Scheme 3
Reaction conditions (i) sodium phenoxide, 1,4-dioxane, rt, 1.5 hours. (ii) 1. Propane-1,3-diamine (1.1 eq.), rt, 3.5 hours; 2. pyridinium hydrochloride. (iii) 17, DCC, HOBT, DIEA, DMF, rt, 24 hours. (v) 1. AcCL, MeOH, 0°C, 30 minutes; 2. HCOOH, CDI, THF, −40°C, 1 hour.
