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Journal of Nucleic Acids
Volume 2010 (2010), Article ID 235240, 13 pages
http://dx.doi.org/10.4061/2010/235240
Research Article

Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide- -Deoxyguanosine Hybrids

1School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
2Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15-8 Shiomi-cho, Choshi, Chiba 288-0025, Japan

Received 22 May 2009; Revised 19 September 2009; Accepted 9 November 2009

Academic Editor: Mitsuo Sekine

Copyright © 2010 Etsuko Kawashima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pyrrolepolyamide- -deoxyguanosine hybrids (Hybrid 2 and Hybrid 3) incorporating the 3-aminopropionyl or 3-aminopropyl linker were designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Hybrid 1). Evaluation of the DNA binding sequence selectivity of pyrrolepolyamide- -deoxyguanosine hybrids was performed by CD spectral and analyses. It was shown that Hybrid 3 possessed greater binding specificity than distamycin A, Hybrid 1 and Hybrid 2.