DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences

<table>Mono- and bis-intercalating compounds inducing local destabilization of the DNA helix. (a) Structure of the compounds. (b) Three-dimensional organisation of <i>morpholino doxorubicin</i> bound to d(CGTACG) (left panel) and of <i>ellipticine</i> (right panel) intercalated between adjacent base pairs (from crystallographic data [mmdbId:52942<svg height="12.9125" id="M8" style="vertical-align:-1.95624pt" version="1.1" viewbox="0 0 5.3249998 12.9125" width="5.3249998" xmlns="http://www.w3.org/2000/svg">
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</svg> and [mmdbId:52189<svg height="12.9125" id="M9" style="vertical-align:-1.95624pt" version="1.1" viewbox="0 0 5.3249998 12.9125" width="5.3249998" xmlns="http://www.w3.org/2000/svg">
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</svg>, respectively, [<a href="/journals/jna/2010/290935/#B72">73</a>, <a href="/journals/jna/2010/290935/#B73">74</a>]).</table>

Journal of Nucleic Acids

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Figure 2

Figure 2: DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences 