DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences
Mono- and bis-intercalating compounds inducing local destabilization of the DNA helix. (a) Structure of the compounds. (b) Three-dimensional organisation of morpholino doxorubicin bound to d(CGTACG) (left panel) and of ellipticine (right panel) intercalated between adjacent base pairs (from crystallographic data [mmdbId:52942 and [mmdbId:52189, respectively, [73, 74]).
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