DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences
Platinium derivatives. (a) Examples of platinated agents inducing local destabilization of the DNA helix. (b) The three-dimensional organization of cisplatin bound to DNA are drawn from crystallographic data [mmdbId:47796  and evidenced strong DNA bending induced by cisplatin on a duplex DNA decamer oligonucleotide that fits with the L-shape angle of HMG-box DNA-binding domain.
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