Modulation of the Ribonucleotide Reductase-Antimetabolite Drug Interaction in Cancer Cell Lines

Figure 3

Western blots of knock-down of TP53 expression in four NSCLC cell lines by RNA interference. TP53-specific siRNA reduced TP53 protein expression to undetectable levels in A549 and H292 and greater then 10-fold in H23 and H460, while random control siRNA did not affect TP53 or RRM1 expression.