Table 1: Repair/transcription factors and their functions.

FactorsRole in NERRole in transcription

TFIIHOpens DNA around the damage.
Favors 5 incision by ERCC1-XPF.
Opens DNA around the promoter.
Phosphorylates the CTD of RNA-Pol II.
Phosphorylates NR and coactivators.

XPGIncises DNA in 3 from the lesionInvolved in NR-dependent transcription.
Stabilizes the interaction of CAK to the core TFIIH.

CSBTC-NER-specific factor.
Recruits NER factors to stalled RNA-Pol II.
Chromatin-remodeling factor (SWI-SNF family).
Reinitiates transcription after DNA damage removal.

XPCRecognition of lesionsInvolved in NR-dependent transcription.
Removal of 5meC
Chromatin modification?

XPAVerification of lesions Involved in NR-dependent transcription.
Removal of 5meC
Chromatin modification?

XPFIncises DNA in 𝟑 from the lesionInvolved in NR-dependent transcription.
Removal of 5meC,
Chromatin modification?
Incision?

In bold, the new NER factors involved in transcription.