Translesion Synthesis Polymerases in the Prevention and Promotion of Carcinogenesis

Figure 4

Immunohistochemical analysis of Pol𝜅, Pol𝜄, and Pol𝜂 expression in primary glioma tissues (g) and normal brain tissues (n). Paraffin-embedded tissue microarrays comprising 104 primary glioma specimens from WHO grades I-IV were stained for Pol 𝜅, Pol 𝜄, or Pol 𝜂. Representative images of Pol 𝜅, Pol 𝜄, and Pol 𝜂 expression: Aa, Ab, Ba, Bb, Ca, and Cb, normal brain tissue; Ac, Ad, Bc, Bd, Cc, and Cd, pilocytic astrocytoma (WHO grade I); Ae, Af, Be, Bf, Ce, and Cf, diffuse astrocytoma (WHO grade II); Ag, Ah, Bg, Bh, Cg, and Ch, anaplastic astrocytomas (WHO grade III); Ai, Aj, Bi, Bj, Ci, and Cj, glioblastoma multiforme (WHO grade IV); magnification: X100 (Aa, Ac, Ae, Ag, Ai, Ba, Bc, Be, Bg, Bi, Ca, Cc, Ce, Cg, and Ci) and X400 (Ab, Ad, Af, Ah, Aj, Bb, Bd, Bf, Bh, Bj, Cb, Cd, Cf, Ch, and Cj). Reproduced with permission from Wang et al. [66].