Journal of Nucleic Acids

Review Article

Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

Table 5

Genetic polymorphisms in the BER pathway and lung cancer risk: XRCC1 Arg280His polymorphism.
Author, published year (reference no.)EthnicityNo. of
Cases/
controls		Source of controlsOR (95% CI) 4 4 6 / 6 2 2 Quality control of genotyping
Arg/HisArg/His or His/His
Ratnasinghe et al., 2001 [34]Asian 1 1 1 / 1 1 0 Population1.40
(0.70–2.60)		1.60
(0.90–2.90)		 Replication (random sample)
Mirsa et al., 2003 [39]Caucasian ‡ Population1.12
(0.70–1.80)		1.17
(0.73–1.87)		 Replication (random samples)
Hung et al., 2005 [25]Mostly composed of Caucasians2,088/2,092Hospital0.95
(0.77–1.18)		0.95
(0.77–1.17)		 Replication (random samples)
Vogel et al., 2004 [23]Caucasian 3 2 4 / 3 7 7 Population0.98
(0.53–1.79)		1.01
(0.56–1.85)		 Replication (random samples)
Schneider et al., 2005 [45]Caucasian 2 3 8 / 2 4 2 Hospital0.93
(0.59–1.44)		0.97
(0.63–1.53)		 None
Shen et al., 2005 [46]Asian 1 1 0 / 1 1 0 Population1.14
(0.60–2.18)		1.29
(0.69–2.41)		 None
Zienolddiny et al., 2006 [26] 1 1 2 / 2 9 6 Caucasian 2 5 4 / 2 8 0 Population1.53
(0.85–2.78)		1.45
(0.82–2.56)		 Replication (All samples)
Yin et al., 2007 [47]Asian ∗ ∗ Hospital0.73
(0.46–1.16)		0.72
(0.46–1.12)		 None
De Ruyck et al., 2007 [30]Caucasian 𝑄 Hospital0.26
(0.06–0.87)		0.26
(0.06–0.87)		 None
Chang et al., 2009 [33]Latino 4 5 5 / 5 6 1 Population1.11
(0.53–2.20)		1.08
(0.53–2.10)		 Replication (random samples)
Chang et al., 2009 [33]African-American ∗ Population ∗ ∗ ‡ Replication (random samples)
Summary 9 5 % No. of populations Cochran 9 0 test for heterogeneity
Arg/HisArg/His or His/His
All104,030/4,5320.96
(0.83–1.11)		0.99
(0.83–1.19)		0.5250.281
Caucasian (mostly composed of Caucasians)53,209/3,3950.95
(0.80–1.13)		0.96
(0.80–1.17)		0.4000.357
Asian3 9 5 % 0.99
(0.66–1.48)		1.10
(0.66–1.84)		0.2360.076
𝑄 Crude odds ratio and 95% confidence interval.
𝑃 = . 0 2 4 Based on random effects model.
∗ Excluded from the meta-analysis because genotype distribution of control population was not in Hardy-Weinberg equilibrium.