Research Article

Structural Properties of G,T-Parallel Duplexes

Table 1

Sequences of the G,T-parallel clamps, control oligonucleotides, and their targets.

No.TypeSequence

1Parallel clamp 3 -GTTGGTGGTGT- 5 -AGAGGAGGAAG- 3
2Target 1 3 -TCTCCTCCTTC- 5
3Complementary to 2 5 -AGAGGAGGAAG- 3
4Parallel clamp 3 -TGTGGTGGTTG- 5 -(EG)6- 5 -GAAGGAGGAGA- 3
5Parallel clamp 3 -TGTGGTGGTTG- 5 -(EG)6- 5 -GAAGGANGGANGA- 3
6Parallel clamp 3 -TGTGGTGGTTG- 5 -(EG)6- 5 -GANANGGANGGANGA- 3
7Parallel clamp 3 -TGTGGTGGTTG- 5 -(EG)6- 5 -GAAGNAGGNAGA- 3
8Target 2 3 -CTTCCTCCTCT- 5
9Control 3 -GGTTGGTTGGT- 5 -(EG)6- 5 -GAAGGANGGANGA- 3
10Complementary to 8 5 -GAAGGAGGAGA- 3
11 2 -OMe-RNA target 2 3 -CUUCCUCCUCU- 5

AN = 8-aminoadenine, G N = 8-aminoguanine, -(EG)6 = hexaethyleneglycol, C,U = 2 -O-methyl-RNA.